Proteomic Identification of New Biomarkers and Application in Thyroid Cytology

Torres‐Cabala, Carlos A.; Bibbo, Marluce; Panizo-Santos, Ángel; Barazi, Heba; Krutzsch, Henry C.; Roberts, David D.; Merino, María J.

doi:10.1159/000326006

Cited by 50 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In thyroid tissue, this isoform was detected in benign tumours as well as in malignant lesions, showing a strong positivity in follicular thyroid carcinomas (Torres-Cabala et al, 2006). However, in contrast with these previous studies, our results did not detect any overexpression in the relative gene expression of this isoform in the tumours and cell lines analysed.…”

Section: Discussioncontrasting

confidence: 99%

The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

Mato

Barceló-Batllori

Orera

et al. 2015

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 99%

The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

Mato

Barceló-Batllori

Orera

et al. 2015

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…There was no significant difference in Gal-3 immunostaining between widely invasive follicular carcinoma and minimally invasive follicular carcinoma. This result is similar to that of Fernandez et al (16) and Torres-Cabala et al (21). This result is also close to the results of Weber et al (6) and Sapio et al (22) with (44%) and (40%) respectively positive cases of follicular carcinoma with Gal-3.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Thyroid Nodules Using Thyroid Peroxidase and Galectin-3:an Immunohistochemical Study

Elkateb

Ahmed

Mohammed

et al. 2013

Zagazig University Medical Journal

View full text Add to dashboard Cite

Background and aim: Thyroid gland carcinoma is a very prevalent neoplasia worldwide. The majority of malignant and benign lesions of the thyroid can be cytologically established. However, to distinguish between malignant and benign lesions histological demonstration is often required for a precise diagnosis. The aim of this study is to detect the ability of thyroid peroxidase (TPO) and to differentiate between thyroid malignant and non-malignant thyroid nodules. Methods: 50 formalin-fixed, paraffin embedded tissue blocks of different thyroid lesions were previously diagnosed and were sectioned at 3-4 μ thick and stained with hematoxylin and eosin (H&E) stain to confirm the histopathologic diagnosis, assess the subtypes of the lesions and assess the histopathologic grading and then were subjected to galectin-3 (Gal-3) and thyroid peroxidase (TPO) immunostaining. Results: In this retrospective histologic study, galectin-3 had a sensitivity of 93.3% for papillary thyroid carcinoma and 50% for follicular thyroid carcinoma. Thyroid peroxidase (TPO) had a sensitivity of 60% for papillary and 12.5% for follicular carcinoma. The combination of galectin-3 and TPO had a sensitivity of 100% for papillary and 50% for follicular carcinoma. Conclusion: This study confirms previous observations that galectin-3 alone is highly sensitive for papillary carcinoma but not adequately sensitive for follicular carcinoma. The combination of galectin-3 and TPO is complementary as a diagnostic and prognostic tool for patients with papillary carcinoma.

show abstract

“…Firstly, the cytomorphological cytoplasmic and nuclear features appear more obvious on cytological smears, and secondly, for practical purposes, we do not routinely utilize immunohistochemical stains for diagnostic purposes (references). Nevertheless, special immunohistochemical stains, genetic mutation analysis, and proteomic biomarkers are being increasingly utilized and considered promising tools to identify malignant thyroid aspirates [34,35]. …”

Section: Discussionmentioning

confidence: 99%

Application of the Bethesda System for Reporting Thyroid Cytopathology in the Eastern Province of Saudi Arabia: Phase I Pilot Retrospective Analysis

et al. 2013

View full text Add to dashboard Cite

We analyzed and evaluated our adequacy rate and the classification of our thyroid aspirates using the Bethesda System for Reporting Thyroid Cytopathology (BSRTC). All thyroid fine needle aspirates that were collected or referred to our institution were reviewed and reclassified according to the BSRTC. The results were tabulated and analyzed. Those with histological resection were correlated with our revised cytopathological evaluation using the BSRTC. A total of 205 thyroid aspirates from 186 patients were reviewed. There were 149 females (80%) and 37 males (20%) ranging in age from 23 to 81 (average age 48) years. All slides were reclassified using the BSRTC. The previous interpretations were not consistent with any apparent standards. The nondiagnostic rate was found to be 22%. Five cases were considered false negative and were upgraded to a more serious category with higher risk of malignancy. The high unsatisfactory rates can be reduced by an adequacy interpretation at the time of the procedure. The risk of malignancy in our cohort increased with each increase in the BSRTC category (I-VI). Communication about and awareness of the BSRTC and its implications by all our clinicians is a prime target of this study and is still work in progress. Hopefully, this study will increase the awareness of the BSRTC and its intended benefits in our region.

show abstract

Proteomic Identification of New Biomarkers and Application in Thyroid Cytology

Cited by 50 publications

References 37 publications

The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

Evaluation of Thyroid Nodules Using Thyroid Peroxidase and Galectin-3:an Immunohistochemical Study

Application of the Bethesda System for Reporting Thyroid Cytopathology in the Eastern Province of Saudi Arabia: Phase I Pilot Retrospective Analysis

Contact Info

Product

Resources

About