2024
DOI: 10.1002/acn3.52134
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Proteomic networks of gray and white matter reveal tissue‐specific changes in human tauopathy

Ashlyn G. Johnson,
Eric B. Dammer,
James A. Webster
et al.

Abstract: ObjectiveTo define tauopathy‐associated changes in the human gray and white matter proteome.MethodWe applied tandem mass tagged labeling and mass spectrometry, consensus, and ratio weighted gene correlation network analysis (WGCNA) to gray and white matter sampled from postmortem human dorsolateral prefrontal cortex. The sampled tissues included control as well as Alzheimer's disease, corticobasal degeneration, progressive supranuclear palsy, frontotemporal degeneration with tau pathology, and chronic traumati… Show more

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