Proteomics of inflammatory and oxidative stress response in cows with subclinical and clinical mastitis

Turk, Romana; Piras, Cristian; Kovačić, Mislav; Samardžija, Marko; Ahmed, Hany; Canio, Michele De; Urbani, Andrea; Meštrić, Zlata Flegar; Soggiu, Alessio; Bonizzi, L.; Roncada, Paola

doi:10.1016/j.jprot.2012.05.021

Cited by 94 publications

(72 citation statements)

References 88 publications

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“…High haptoglobin was reported in cattle with mastitis (Conner et al, 1986;Spooner & Miller, 1971), liver abscesses, C. pyogenes infected abscesses, in calves exposed to the Pasteurella haemolytica (Spooner & Miller, 1971), pyometra, traumatic reticulitis, traumatic pericarditis and abomasal displacement (Makimura & Suzuki, 1982;Godson et al, 1996). Changes in the levels of some acute phase proteins including haptoglobin in cows with mastitis were studied by Turk et al (2012). The increased APP were attributed by the authors to an increase of proinflammatory cytokines and oxidative stress during mastitis.…”

Section: Discussionmentioning

confidence: 99%

Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Georgieva¹,

Vasilev²,

Karadaev³

et al. 2018

BJVM

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Section: Discussionmentioning

confidence: 99%

Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Georgieva¹,

Vasilev²,

Karadaev³

et al. 2018

BJVM

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“…Inter-alpha-trypsin inhibitor heavy chain H4 is a possible marker of infection in bovine mastitis (Turk et al, 2012) and is involved in extracellular matrix stabilization. It is a positive APP regulated by IL-6 and correlated with liver development and regeneration (Chandler et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

Sampaio

Fidélis

Marques

et al. 2015

Veterinary Parasitology

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“…In addition, subclinical mastitis causes a similar reduction of reproductive performance as mastitis (Schrick et al, 2001). High SCC in milk has been considered as the only evidence that helps in the diagnosis of subclinical mastitis (Turk et al, 2012). Therefore, identifying new biomarkers for subclinical mastitis may help to develop an easy test aiming at predicting milk suitability for further milk processing.…”

Section: Introductionmentioning

confidence: 99%

A proteomic perspective on the changes in milk proteins due to high somatic cell count

Zhang

Boeren

Hooijdonk

et al. 2015

Journal of Dairy Science

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Although cows with subclinical mastitis have no difference in the appearance of their milk, milk composition and milk quality are altered because of the inflammation. To know the changes in milk quality with different somatic cell count (SCC) levels, 5 pooled bovine milk samples with SCC from 10(5) to 10(6) cells/mL were analyzed qualitatively and quantitatively using both one-dimension sodium dodecyl sulfate PAGE and filter-aided sample preparation coupled with dimethyl labeling, both followed by liquid chromatography tandem mass spectrometry. Minor differences were found on the qualitative level in the proteome from milk with different SCC levels, whereas the concentration of milk proteins showed remarkable changes. Not only immune-related proteins (cathelicidins, IGK protein, CD59 molecule, complement regulatory protein, lactadherin), but also proteins with other biological functions (e.g., lipid metabolism: platelet glycoprotein 4, butyrophilin subfamily 1 member A1, perilipin-2) were significantly different in milk from cows with high SCC level compared with low SCC level. The increased concentration of protease inhibitors in the milk with higher SCC levels may suggest a protective role in the mammary gland against protease activity. Prostaglandin-H2 D-isomerase showed a linear relation with SCC, which was confirmed with an ELISA. However, the correlation coefficient was lower in individual cows compared with bulk milk. These results indicate that prostaglandin-H2 D-isomerase may be used as an indicator to evaluate bulk milk quality and thereby reduce the economic loss in the dairy industry. The results from this study reflect the biological phenomena occurring during subclinical mastitis and in addition provide a potential indicator for the detection of bulk milk with high SCC.

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Proteomics of inflammatory and oxidative stress response in cows with subclinical and clinical mastitis

Cited by 94 publications

References 88 publications

Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

A proteomic perspective on the changes in milk proteins due to high somatic cell count

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