Proteomics on the role of muscone in the “consciousness-restoring resuscitation” effect of musk on ischemic stroke

Han, Bingbing; Zhao, Yan‐Gang; Yao, Jianquan; Li, Na; Fang, Tianhe; Wang, Yuan; Meng, Zhaoqing; Liu, Wei

doi:10.1016/j.jep.2022.115475

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Its expression is prevalent in microglia, where it contributes to the orchestration of microglia polarization, suppression of inflammation in cerebral ischemic injury, and facilitation of tissue repair ( SHAN et al, 2018 ; LI J. et al, 2020 ). Muscone , the primary active constituent of musk , has been extensively employed in the management of cerebral ischemia and reperfusion injury ( HAN et al, 2022 ). Muscone exhibits the ability to enhance the expression of Arg1 and CD206 via the PPARγ pathway, thereby significantly augmenting the conversion of microglia into M2 phenotype ( REN et al, 2022 ; LIU et al, 2023 ).…”

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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Ischemic stroke is a prevalent clinical condition affecting the central nervous system, characterized by a high mortality and disability rate. Its incidence is progressively rising, particularly among younger individuals, posing a significant threat to human well-being. The activation and polarization of microglia, leading to pro-inflammatory and anti-inflammatory responses, are widely recognized as pivotal factors in the pathogenesis of cerebral ischemia and reperfusion injury. Traditional Chinese herbal medicines (TCHMs) boasts a rich historical background, notable efficacy, and minimal adverse effects. It exerts its effects by modulating microglia activation and polarization, suppressing inflammatory responses, and ameliorating nerve injury through the mediation of microglia and various associated pathways (such as NF-κB signaling pathway, Toll-like signaling pathway, Notch signaling pathway, AMPK signaling pathway, MAPK signaling pathway, among others). Consequently, this article focuses on microglia as a therapeutic target, reviewing relevant pathway of literature on TCHMs to mitigate neuroinflammation and mediate IS injury, while also exploring research on drug delivery of TCHMs. The ultimate goal is to provide new insights that can contribute to the clinical management of IS using TCHMs.

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Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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“…[66,67] Muscone, an active component of musk, ameliorates the neurological damage mainly through remedying neuronal synaptic connections. [68] DIA proteomics results indicated that Alb, mTOR, Stxbp1, Cltc, Dync1h1, and Sptan1 may be the potential targets of sodium tanshinone IIA sulfonate, a key ingredient from Salvia miltiorrhiza Bunge for treating stroke injuries. [69] Scutellarin alleviates stroke-induced oxidative stress injury via downregulating aldose reductase and its downstream targets Nox1, Nox2, and Nox4 that lead to reactive oxygen species-induced oxidative damage.…”

Section: Proteomic Analysis Of Ais With Therapeutic Interventionsmentioning

confidence: 99%

Proteomic investigations of acute ischemic stroke in animal models: a narrative review

Sun

Wei

2022

J Bio-X Res

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Acute ischemic stroke (AIS), a neurological injury resulting from blood clots, is the second most common cause of death worldwide. Novel therapeutics are urgently needed. Rapid developments in instrumentation and bioinformatics have resulted in increased use of mass spectrometry-based proteomics as an effective tool for the in-depth study of AIS. This review focuses on proteomics investigations of AIS in animal models. We highlight the study findings in system-wide protein abundance changes and molecular mechanisms underlying AIS with or without therapeutic intervention, as well as prestroke prognosis investigations. This review reveals that common molecular pathways related to ischemic injury and spontaneous recovery have been uncovered and part of AIS-changed proteins have been repeatedly identified, indicating the promise of proteomics in generating novel therapeutic targets and biomarker candidates. We also discuss challenges, alleviating strategies, and perspectives of mass spectrometrybased proteomics in AIS research and call for a broad application of systems-level investigations on preclinical AIS molecular mechanism elucidation, target discovery and validation, and therapeutics development.

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“…Forest musk deer, a kind of small ruminant, is famous for its musk secreted in the musk pot of adult male individuals. Musk has a variety of pharmacological activities, such as playing a role in cerebrovascular diseases and cardiovascular diseases as well as in the nervous system and cancer [1][2][3][4][5]. In general, mature musk is a kind of dark brown solid in the same way as earwax [6], whereas the immature musk in the musk pot was white and stench and it is still different in composition from the mature musk [7,8].…”

Section: Introductionmentioning

confidence: 99%

Correlation Analysis between Muskrat (Ondatra zibethicus) Musk and Traditional Musk

Shi

Zeng

Zhao

et al. 2023

Animals

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Muskrat musk is considered to be a potential substitute for traditional musk. However, little is known about the similarity between muskrat musk and musk, and whether it is related to muskrat age. In this study, muskrat musk (MR1, MR2, and MR3) were from 1, 2, and 3-year-old muskrats, respectively, and white musk (WM) and brown musk (BM) were picked from male forest musk deer. The results indicated that muskrat musk had higher similarity to WM than BM. Further research showed that RM3 had the highest matched degree with WM. By significantly different metabolite analysis, we found that 52 metabolites continue to increase from 1- to 3-year-old muskrats. In total, 7 and 15 metabolites were significantly decreased in RM1 vs. RM2 and RM2 vs. RM3, respectively. Meanwhile, 30 and 17 signaling pathways were observed from increased and decreased metabolites, respectively. The increased metabolites mainly entailed enrichment in amino acid biosynthesis and metabolism, steroid hormone biosynthesis, and fatty acid biosynthesis. In conclusion, muskrat musk from three-year-old muskrat is a relatively good substitute for white musk, and the result also implies that these biological processes of amino acid biosynthesis and metabolism, steroid hormone biosynthesis, and fatty acid biosynthesis are beneficial to the secretion of muskrat musk.

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Proteomics on the role of muscone in the “consciousness-restoring resuscitation” effect of musk on ischemic stroke

Cited by 9 publications

References 54 publications

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Proteomic investigations of acute ischemic stroke in animal models: a narrative review

Correlation Analysis between Muskrat (Ondatra zibethicus) Musk and Traditional Musk

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