Prothrombin time, activated partial thromboplastin time and platelet counts of type II diabetes mellitus: a comparative study

Abstract

Background The incidence of cardiovascular disease due to thrombosis is 2-4 folds greater in diabetic patients. Prothrombin time, activated partial thromboplastin time and platelet count are hematological indices that give an insight into the coagulation status. Hence, this study aims to assess the coagulation status of type II diabetic patients. Methods A comparative cross-sectional study was conducted at Bahir Dar Felege Hiwot referral hospital, Northwest Ethiopia. A total of 40 treated type II diabetic, 40 untreated diabetics and 40 non-diabetic subjects were included. After taking informed consent, structured questionnaire was used to collect socio-demographic data. Following interview, 4 ml of blood was collected to determine PT, aPTT and platelet count of the three groups. The data were entered into SPSS version 20 and analyzed. One-way ANOVA was used to compare means of PT, aPTT and platelet count among the groups. A P value less than 0.05 was considered as statistically significant. Results The mean aPTT of non-diabetic, treated and untreated type II diabetic patient was 32.8 ± 4.12 s, 34.4 ± 5.3 s, and 25.42 ± 8.46 s, respectively. The proportion of untreated diabetic patients with normal PT, aPTT and platelet counts was 60.0%, 7.5 and 92.5%, respectively. There was a significant shortening of aPTT in untreated diabetic as compared to both treated and nondiabetic controls (P < 0.001). Conclusions Shortening of aPTT in untreated type II diabetic patients might be useful marker in patients with diabetes. Therefore, monitoring the aPTT in newly diagnosed diabetic patients is important.

Gestational diabetes mellitus is associated with antenatal hypercoagulability and secondary hyperfibrinolysis: a case control study of Chinese women

“…Furthermore, PT and APTT, measured between the 20th and 24th gestational weeks, were significantly lower in patients with GDM than in healthy people [29] . In another study, the mean APTTs of non-diabetic, treated, and untreated type 2 diabetic patients were 32.8 ± 4.12 sec, 34.4 ± 5.3 sec, and 25.4 ±8.5 sec, respectively, which showed that APTT was lower in diabetic patients and that this defect was normalized by diabetes treatment [31] . This might help to explain the significantly higher APTT in GDM patients identified in the present study.…”

“…The shortening of APTT in type 2 diabetic patients has been described as indicating a high risk of a hypercoagulable state [31] . It has also been shown that the increase in fibrinogen and the reduction in fibrinolytic activity in GDM are more similar to the changes present in type 2 than in type 1 diabetic patients [32] , and it is thought that a shorter APTT is a marker of venous thromboembolism risk [33,34] .…”

Gestational diabetes mellitus is associated with antenatal hypercoagulability and secondary hyperfibrinolysis: a case control study of Chinese women

“…Furthermore, PT and APTT, measured between the 20th and 24th gestational weeks, were significantly lower in patients with GDM than in healthy people [12] . In another study, the mean APTTs of non-diabetic, treated, and untreated type 2 diabetic patients were 32.8 ± 4.12 sec, 34.4 ± 5.3 sec, and 25.4 ±8.5 sec, respectively, which showed that APTT was lower in diabetic patients and that this defect was normalized by diabetes treatment [29] . This might help to explain the significantly higher APTT in GDM patients identified in the present study.…”

“…The shortening of APTT in type 2 diabetic patients has been described as indicating a high risk of a hypercoagulable state [29] . It has also been shown that the increase in fibrinogen and the reduction in fibrinolytic activity in GDM are more similar to the changes present in type 2 than in type 1 diabetic patients [30] , and it is thought that a shorter APTT is a marker of venous thromboembolism risk [31,32] .…”

Treatment modality, diabetic control and blood homeostasis in type 2 diabetes mellitus patients in Basra

“…Treatment manner had no effect on mean PT or APTT and further studies are needed to bring about understanding of diabetic control and blood homeostasis. (APTT) in T2DM patients -as APTT and PT, as well as platelet counts are hematological indicators for patient coagulation states [6].…”