Protocol biopsies in renal transplant patients: three-years’ follow-up

Veronese, Francisco Veríssimo; Noronha, Irene L.; Manfro, Roberto Ceratti; Edelweiss, Maria Isabel Albano; Goldberg, J.; Oliveira, Stela; Oliveira, Isabel; Leitão, Therezinha Gauri; Gonçalves, Luiz Felipe Santos

doi:10.1016/s0041-1345(02)02608-8

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…The occurrence of histologic signs of acute cellular rejection in the absence of graft dysfunction, a condition termed SAR, is well established in the literature [2–20]. Already in the 1980s, Burdick et al .…”

Section: Subclinical Acute Rejection – Definition and Incidencesmentioning

confidence: 99%

Section: Subclinical Acute Rejection – Definition and Incidencesmentioning

confidence: 99%

“…The occurrence of histologic signs of acute cellular rejection in the absence of graft dysfunction, a condition termed SAR, is well established in the literature [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Already in the 1980s, Burdick et al [2,3] suggested that cellular infiltrates are not necessarily associated with clinically overt rejection.…”

Section: Subclinical Acute Rejection -Definition and Incidencesmentioning

confidence: 99%

“…In most studies evaluating surveillance biopsies, SAR is defined and classified according to the Banff scheme (Banff grade I or greater) analogous to clinical acute rejection [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Rush et al defined SAR as an increase in serum creatinine <10% associated with the histologic diagnosis of acute rejection (at least i2t2) according to the Banff classification [4,5,9,11,24].…”

Section: Subclinical Acute Rejection -Definition and Incidencesmentioning

confidence: 99%

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Protocol biopsies after kidney transplantation

Böhmig¹,

Regele²,

Hörl³

2005

Transplant Int

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Numerous studies have investigated features of allograft injury in renal biopsies obtained in stable kidney transplants. Evaluation of protocol biopsies has revealed a considerably high prevalence of subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) already in early phases after transplantation. The meanwhile well-established association of SAR and CAN in protocol biopsy with long-term allograft failure and the finding of superior allograft outcome after treatment of SAR in a randomized prospective study may point to clinical relevance of this procedure. In this review, potential benefits and risks associated with kidney allograft biopsy in stable renal transplant recipients are discussed.

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Section: Subclinical Acute Rejection – Definition and Incidencesmentioning

confidence: 99%

Section: Subclinical Acute Rejection – Definition and Incidencesmentioning

confidence: 99%

Section: Subclinical Acute Rejection -Definition and Incidencesmentioning

confidence: 99%

Section: Subclinical Acute Rejection -Definition and Incidencesmentioning

confidence: 99%

See 2 more Smart Citations

Protocol biopsies after kidney transplantation

Böhmig¹,

Regele²,

Hörl³

2005

Transplant Int

View full text Add to dashboard Cite

show abstract

“…There is a fairly substantial literature on protocol biopsies in adult renal transplant recipients, and a smaller literature on pediatric recipients. These studies show a variable incidence of subclinical acute rejection, ranging from 2.6-100%, with many reports in the 25-30% range (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). There is also a literature demonstrating an incidence of subclinical chronic allograft nephropathy (CAN) (6,8,10,13,14,(17)(18)(19)(20)(21)(22)(23)(24)(25), and a suggestion that the presence of CAN with vasculopathy is a poor prognostic factor for long-term outcome (8).…”

mentioning

confidence: 99%