Protocol implementation in hospital infection control practice: an Italian experience of preoperative antibiotic prophylaxis

Impact of local guidelines and an integrated dispensing system on antibiotic prophylaxis quality in a surgical centre

“…8,9,25 However, the increased percentage of appropriate SAP after IDS and local protocol implementation was higher than in other similar studies. 7,8 The results of SAP appropriateness obtained in the postimplementation stage were better than those obtained by Skledar 9 or Talon et al 8 In the postimplementation stage, 4.4% of antibiotic prophylaxis was started after the surgical procedure. This result was better than that found by Talon et al, 8 or Frighetto et al 12 but lower than obtained by Skledar.…”

“…The results obtained in this study appear to be more conclusive than in other studies. [6][7][8][9][10][11] Similarly, when reasons for inappropriateness of SAP have been analysed, timing of antimicrobial administration has appeared to be the main cause of misuse, followed by the choice of antimicrobial agent and the length of therapy. 9,10,12 Two other reasons for SAP inappropriateness are a high variability in SAP criteria between different medical teams, even between surgeons from the same medical team, and poor organization.…”

Influence of pregnancy on ceftriaxone, cefazolin and gentamicin pharmacokinetics in caesarean vs. non-pregnant sectioned women

“…To prevent postoperative infection in patients undergoing caesarean section, antibiotics have traditionally been given after the cord clamping, but this has the disadvantage that adequate antibiotic levels are not reached in the mother until after the incision has been made (1–11). A large number of investigations have claimed greater efficacy by administering drugs prior to surgical incision, without exposing the infant to high antibiotic levels (12–17). Comparative studies of antibiotic prophylaxis show the same risk of infections (18–25).…”

Audit of the use of antimicrobial prophylaxis in nasal surgery at a specialist Australian hospital

“…A prospective study of the use of AMP for 687 surgical procedures in 18 hospitals in Eastern France found that in over 50% of procedures AMP was used inappropriately 5 . Other studies of the use of AMP have reported rates of inappropriate use ranging 31−97% 8−10 .…”