Protocols for Topical and Systemic Oxygen Treatments in Wound Healing

Schlanger, Richard; Wallace, W. Angus; Bergdall, Valerie; Bartlett, Robert H.; Sen, Chandan K.

doi:10.1016/s0076-6879(04)81037-1

Cited by 18 publications

(13 citation statements)

References 20 publications

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“…The level of oxygenation achieved with 203 kPa pressure in HBO therapy can range from 300 to 1200 mmHg, which far exceeds the Po 2 of healthy skin or that achieved in the wound tissue with TO. 15,19 The present study establishes a link between VEGF gene expression and healing outcome for TO therapy. If validated in a larger population, this finding could help identify a biomarker to gauge response to TO treatment.…”

Section: Discussionsupporting

confidence: 52%

“…One potential reason for this is the difference in the level of wound tissue oxygenation achieved with each of these modalities. The level of oxygenation achieved with 203 kPa pressure in HBO therapy can range from 300 to 1200 mmHg, which far exceeds the P o 2 of healthy skin or that achieved in the wound tissue with TO 15,19 . The present study establishes a link between VEGF gene expression and healing outcome for TO therapy.…”

Section: Discussionmentioning

confidence: 59%

“…Treatments that followed the collection of wound edge biopsies were performed in the clinic. The TO device (GWR Medical, Chadds Ford, PA, USA) is a single‐use disposable device that connects to a portable oxygen source, as described previously 19 . The device inflates to approximately 101 kPa pressure and has a release valve in the event of excess pressure build up.…”

Section: Methodsmentioning

confidence: 99%

“…The TO device (GWR Medical, Chadds Ford, PA, USA) is a single-use disposable device that connects to a portable oxygen source, as described previously. 19 The device inflates to approximately 101 kPa pressure and has a release valve in the event of excess pressure build up. Representatives from the manufacturer of the TO devices provided patients with instructions on how to use the device.…”

Section: Supplemental Oxygen Therapymentioning

confidence: 99%

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Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Gordillo¹,

Roy²,

Khanna³

et al. 2008

Clin Exp Pharma Physio

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101

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1.Chronic wounds, especially in diabetics, represent a serious threat to human health. 2.Correcting a compromised state of tissue oxygenation by the administration of supplemental O 2 is known to benefit wound healing. Beyond its role as a nutrient and antibiotic, O 2 supports wound healing by driving redox-signaling.3. HBO (hyperbaric oxygen) therapy is widely used and approved by CMS to treat specific ulcerations. The current literature supports that approaches to topically oxygenate wounds may be productive. 4.Here, we present the results of two simultaneous studies testing the effects of HBO and portable topical oxygen (TO) therapies. These two therapeutic approaches have several contrasting features. 5.A total of 1854 patients were screened in outpatient wound clinics for non-randomized enrollments into the HBO (n=32, 31% diabetic) and TO (n=25, 52% diabetic) studies.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Supplemental Oxygen Therapymentioning

confidence: 99%

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Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Gordillo¹,

Roy²,

Khanna³

et al. 2008

Clin Exp Pharma Physio

Self Cite

101

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“…71 The lack of a formal study in this regard has been offset by several reviews, case series, and experimental studies on the effect of topically administered oxygen at the wound surface that seem to indicate a benefit in promoting wound repair. 154,[159][160][161][162][163][164][165][166][167][168][169] While several RCTs with different devices have been ongoing, there have been no publications to date comparing 12-week healing rates with those of standard care.…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,823

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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