Proton beam characterization in the experimental room of the Trento Proton Therapy facility

Tommasino, Francesco; Rovituso, Marta; Fabiano, Silvia; Piffer, Silvio; Manea, C.; Lorentini, Stefano; Lanzone, S.; Wang, Z.; Pasini, M.; Burger, W. J.; Tessa, Chiara La; Scifoni, E.; Schwarz, Marco; Durante, Marco

doi:10.1016/j.nima.2017.06.017

Cited by 58 publications

(60 citation statements)

References 14 publications

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“…A dipole magnet at the entrance of the experimental cave allows switching the beam to one of the two available beam lines, where a fix horizontal pencil beam is delivered. The characteristics of the pencil beam in air are summarized in two publications [9,11].…”

Section: Methodsmentioning

confidence: 99%

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A new facility for proton radiobiology at the Trento proton therapy centre: Design and implementation

et al. 2019

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We present a new facility dedicated to radiobiology research, which has been implemented at the Trento Proton Therapy Centre (Italy). A dual-ring double scattering system was designed to produce irradiation fields of two sizes (i.e. 6 and 16 cm diameter) starting from a fix pencil beam at 148 MeV. The modulation in depth was obtained with a custommade range modulator, optimized to generate a 2.5 cm spread-out Bragg peak (SOBP). The resulting irradiation field was characterized in terms of lateral and depth-dose profiles. The beam characteristics and the geometry of the setup were implemented in the Geant4 Monte Carlo (MC) code. After benchmark against experimental data, the MC was used to characterize the distribution of dose-average linear energy transfer (LET) associated to the irradiation field. The results indicate that dose uniformity above 92.9% is obtained at the entrance channel as well as in the middle SOBP in the target regions for both irradiation fields. Dose rate in the range from 0.38 to 0.78 Gy/min was measured, which can be adjusted by proper selection of cyclotron output current, and eventually increased by about a factor 7. MC simulations were able to reproduce experimental data with good agreement. The characteristics of the facility are in line with the requirements of most radiobiology experiments. Importantly, the facility is also open to external users, after successful evaluation of beam proposals by the Program Advisory Committee.

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Section: Methodsmentioning

confidence: 99%

“…One beam line is dedicated to physics-oriented research, ranging from detector testing to space radioprotection. A fix pencil beam is delivered, which has been recently characterized as summarized in Tommasino et al [9]. The second beam line is dedicated to radiobiology research.…”

Section: Introductionmentioning

confidence: 99%

A new facility for proton radiobiology at the Trento proton therapy centre: Design and implementation

et al. 2019

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“…The National Institute for Nuclear Physics (INFN) in Italy has several accelerator facilities with biomedical applications, including Laboratori Nazionali del Sud (LNS) in Catania [68], the first center in Italy to treat patients with proton therapy for eye tumors, and the Trento Institute for Fundamental Physics and Applications (TIFPA), where an experimental vault [69] with two beamlines delivering protons with energies up to 230 MeV is available in the local proton therapy center, where two other rooms are equipped with isocentric gantries for treating patients.…”

Section: Infn and Cnaomentioning

confidence: 99%

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

et al. 2020

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Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these facilities is often basic research in nuclear physics, they acknowledge the importance of including biomedical research programs and of interacting with other medical accelerator facilities providing patient treatments. To harmonize the programs, avoid duplications, and foster collaboration and synergism, the International Biophysics Collaboration is providing a platform to several accelerator centers with interest in biomedical research. In this paper, we summarize the programs of various facilities in the running, upgrade, or construction phase.

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“…However the SEU cross section value for a proton environment, derived from the convolution with the probability of energy deposition from protons, was roughly evaluated to be 3.2 • 10 −16 cm 2 /bit in the case of a sensitive depth of 1 µm [11]. To obtain a direct measurements of upset numbers in the channel configuration registers of PAStA, a second test was performed with proton beams [12] at the experimental room of INFN-TIFPA in the proton-therapy Centre of Trento. The device is positioned in front of the beam line outlet and the proton flux on the device was obtained using wire chambers, with an estimated error of 10%.…”

Section: Pos(twepp2019)126mentioning

confidence: 99%

Study of SEU effects in circuits developed in 110 nm CMOS technology

Calvo¹,

Remigis²,

Fisichella³

et al. 2020

Proceedings of Topical Workshop on Electronics for Particle Physics — PoS(TWEPP2019)

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Channel configuration registers of a full size prototype for the custom readout circuit of silicon double-sided microstrips of PANDA Micro Vertex Detector were tested for upset effects. The ASIC is developed in a commercial 110 nm CMOS technology and implements both Triple Modular Redundancy and Hamming Encoding techniques. Results from tests with ion and proton beams show the robustness level of these two techniques against the upset effects and allow the evaluation of that commercial 110 nm technology in the PANDA experiment.

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Proton beam characterization in the experimental room of the Trento Proton Therapy facility

Cited by 58 publications

References 14 publications

A new facility for proton radiobiology at the Trento proton therapy centre: Design and implementation

A new facility for proton radiobiology at the Trento proton therapy centre: Design and implementation

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

Study of SEU effects in circuits developed in 110 nm CMOS technology

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