Proton Beam Radiography in Tumor Detection

Steward, V. W.; Koehler, Andreas

doi:10.1126/science.179.4076.913

Cited by 73 publications

(29 citation statements)

References 3 publications

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“…Directly behind the metal object, the fluence enhancements and depletions are observed near the edge of the metal object. This well-understood effect is sometimes called the edge enhancement effect (Koehler, 1968; Schneider and Pedroni, 1995; Steward and Koehler, 1973a, b). The lateral deflections are predominated by multiple Coulomb scattering.…”

Section: Dicussionmentioning

confidence: 99%

Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

Newhauser¹,

Rechner

Mirković

et al. 2013

Radiation Measurements

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Monte Carlo simulations are increasingly used for dose calculations in proton therapy due to its inherent accuracy. However, dosimetric deviations have been found using Monte Carlo code when high density materials are present in the proton beam line. The purpose of this work was to quantify the magnitude of dose perturbation caused by metal objects. We did this by comparing measurements and Monte Carlo predictions of dose perturbations caused by the presence of small metal spheres in several clinical proton therapy beams as functions of proton beam range, spread-out Bragg peak width and drift space. Monte Carlo codes MCNPX, GEANT4 and Fast Dose Calculator (FDC) were used. Generally good agreement was found between measurements and Monte Carlo predictions, with the average difference within 5% and maximum difference within 17%. The modification of multiple Coulomb scattering model in MCNPX code yielded improvement in accuracy and provided the best overall agreement with measurements. Our results confirmed that Monte Carlo codes are well suited for predicting multiple Coulomb scattering in proton therapy beams when short drift spaces are involved.

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Section: Dicussionmentioning

confidence: 99%

Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

Newhauser¹,

Rechner

Mirković

et al. 2013

Radiation Measurements

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show abstract

“…The concept of the range-edge proton radiography was proposed by Koehler in 1968 [1]. Subsequently, Koehler and others [2][3][4][5] demonstrated that the high-contrast images obtained by proton radiography can provide improved imaging of low contrast lesions in human specimens over conventional x-ray techniques. Hanson described a proton CT method in 1981 [6,7], in which projections necessary for computer tomography (CT) reconstructions were obtained by measuring the proton energy losses.…”

Section: Introductionmentioning

confidence: 97%

Concept and design of charged particle optics using energy Fourier plane collimation

Gao

Tao

Zhou

et al. 2014

Phys. Rev. ST Accel. Beams

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Charged particle radiography has become a promising new approach in the field of transmission radiography because of the invention of the magnetic imaging lens. The using of the imaging lens makes it possible for thick objects to get significantly improved transmission radiography. Currently, the conventional charged particle radiography only uses the information of the flux attenuation and the angular scattering of the transmitted particles to determine the properties of the sample. However, the energy loss of the incident particles introduced by ionizations throughout the object limits the spatial resolution of the image because of the chromatic blur. In this paper a new concept of imaging lens that uses the information of the energy loss is proposed. With a specially designed imaging lens, the information of the energy loss could result in apparent contrast in the final image. This design procedure of the energy loss imaging lens is presented, and a preliminary design is verified by numerical simulations. Experimental demonstration is also expected on a cyclotron at the Institute of Fluid Physics, CAEP.

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“…Proton radiography and tomography as a diagnostic tool was investigated in the early 1970s [1][2][3][4][5] but was more or less abandoned due to the success of X-ray-computed tomography. With the expansion of proton radiation therapy facilities, renewed interest has been placed in the development of a clinical proton radiography or tomography system.…”

Section: Introductionmentioning

confidence: 99%

Spatial resolution of proton tomography: Methods, initial phase space and object thickness

Schneider

Pedroni

Hartmann

et al. 2012

Zeitschrift für Medizinische Physik

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Proton Beam Radiography in Tumor Detection

Cited by 73 publications

References 3 publications

Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

Concept and design of charged particle optics using energy Fourier plane collimation

Spatial resolution of proton tomography: Methods, initial phase space and object thickness

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