Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions

Abstract

Our study showed that 1H-MRS and apparent diffusion coefficients can help in evaluation and differentiation of solid brain lesions.

Diagnostic Value of Diffusion-weighted Magnetic Resonance (MR) Imaging, MR Perfusion, and MR Spectroscopy in Addition to Conventional MR Imaging in Intracranial Space-occupying Lesions

“…DWI has been applied for the assignment of tumor grades or differentiation of tumors, as well as for the diagnosis of ischemic stroke [5,[10][11][12][13][14][15][16]19]. Several investigators found an inverse correlation between the ADC calculated from DW images and tumor cellularity [5,[13][14]16].…”

“…In the literature, some authors reported that the combination of DWI (ADCmin) and MRP (rCBVmax) could be more effective in the differential diagnosis of cerebral tumors [12,18]. The combination of ADC values and MRS findings could be more useful in staging and differential diagnosis of cerebral tumors [5,19]. Additionally, the combination of rCBV and metabolite ratios should be used in differentiating neoplastic-nonneoplastic brain lesions and in grading cerebral gliomas [3,[6][7]9].…”

Apparent diffusion coefficient in the evaluation of cerebral gliomas malignancy

“…A study conducted by Yin et al 16 showed that the ADC values were inversely correlated to the degree of malignancy of gliomas, namely that high grade gliomas had significantly lower ADC and relative ADC (rADC) values in relation to gliomas categorized as low grade. Also, Ristić-Baloš et al 17 reported that DWI can be useful in differentiating benign and malignant tumors from normal parenchyma and in grading gliomas. The results of our research correspond with previous findings from the literature that glial tumors grade II and grade III showed a statistical significance.…”