Proton Oriented-“Smart Depot” for Responsive Release of Ca2+ to Inhibit Peptide Acylation in PLGA Microspheres

Liu, Jiwei; Xu, Yan; Wang, Yonglu; Ren, Hao; Meng, Zhengjie; Liu, Kuntang; Liu, Zhe; Huang, He; Li, Xueming

doi:10.1007/s11095-019-2640-5

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Even though PLA and PLGA nanoparticles showed good biocompatibility and bioavailability in a variety of drug delivery systems, two issues arise with their use. One is the stability of the loaded drug due to ionic interaction between the carboxy terminus of the biopolymer and the N-terminus of a protein-based drug [105,106]. The second is the formation of acidic residues (glycolic and lactic) in an aqueous environment, due to the erosion of the nanoparticle.…”

Section: Polylactic (Pla) Andmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Polylactic (Pla) Andmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…In addition to primary amines, arginine residue has also been identified as acylation site in goserelin and leuprolide having no primary amines [ 128 , 129 ]. Several strategies have been proposed and studied to prevent and minimize peptide acylation in PLGA formulations [ 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ].…”

Section: Stability Of Drugs In Plga Particulate Formulationsmentioning

confidence: 99%

Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System

et al. 2021

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Biopolymeric microparticles have been widely used for long-term release formulations of short half-life chemicals or synthetic peptides. Characterization of the drug release from microparticles is important to ensure product quality and desired pharmacological effect. However, there is no official method for long-term release parenteral dosage forms. Much work has been done to develop methods for in vitro drug release testing, generally grouped into three major categories: sample and separate, dialysis membrane, and continuous flow (flow-through cell) methods. In vitro drug release testing also plays an important role in providing insight into the in vivo performance of a product. In vitro release test with in vivo relevance can reduce the cost of conducting in vivo studies and accelerate drug product development. Therefore, investigation of the in vitro–in vivo correlation (IVIVC) is increasingly becoming an essential part of particulate formulation development. This review summarizes the principles of the in vitro release testing methods of biopolymeric particulate system with the recent research articles and discusses their characteristics including IVIVC, accelerated release testing methods, and stability of encapsulated drugs.

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