Proton pump inhibitor–induced vitiligo following airborne occupational sensitization

Kim, Dong Chan; Kang, Hee Young

doi:10.1111/cod.13919

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Contact Dermatitis Due To Ppi1

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2023

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“…In an occupational airborne contact dermatitis (CD) due to PPI, the erythematous lesions of the face predominating on eyelids led to vitiligo lesions, 85 patch tests were positive with the handled PPI (pantoprazole and rabeprazole). 85 In the literature, 10 cases of occupational CD due to PPI have been reported in workers in pharmaceutical industry or in horse trainers. 86 In all cases it was an airborne eczema predominating on the face, mainly on the eyelids, the neck, arms, and hands.…”

Section: Contact Dermatitis Due To Ppimentioning

confidence: 99%

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Bavbek,

Kepil Özdemir,

Bonadonna

et al. 2023

Allergy

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Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence‐based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in‐depth investigations in the topic.

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Section: Contact Dermatitis Due To Ppimentioning

confidence: 99%