In the present paper, we study nonresonant corrections for experimental measurements of the transition frequencies in the helium atom. Having attracted more attention, such effects can make a significant contribution to experiments based on one-and two-photon atomic spectroscopy. The quantum interference effects in the measurements of n 3 S 1 − 3 3 D 1 (n = 3, 4, 5) transition frequencies based on Doppler-free two-photon spectroscopy, are considered as a possible source of current discrepancy between the experimental and theoretical data. We demonstrate that line profile asymmetry caused by the quantum interference of fine sub-levels of the 3 D J (J = 1, 2, 3) state can reach tenths of a megahertz for different experimental conditions. Thus, previously unaccounted nonresonant corrections should be taken in next-generation experimental measurements of transitions frequencies in helium. However, they could not completely eliminate the current imbalance in the study of helium spectra and the question is still open.