Protonation equilibria of glycine, 1,10-phenanthroline and 2,2-bipyridyl in ethylene glycol–water mixtures

Sarathi, T. V. N. Partha; Rao, G. Nageswara; Vani, P.

doi:10.3184/095422910x12897568832955

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…The amino acid glycine can be protonated at pH values lower than 2 . Upon protonation, the amine moieties have a positive charge, and thus repulsion of the polymer segments is expected along with an increased solubility of the polymer in water.…”

Section: Resultsmentioning

confidence: 99%

Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes

et al. 2019

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The remarkable ability of biological systems to specifically recognize, sort, and process molecules encourages the development of novel bio-inspired membranes and interfaces. Herein, we focus on the functionalization of amphiphilic polystyrene-block-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) with the amino acid glycine yielding polar block segments with primary amine functionalities. Excellent control over the tailored block copolymer (BCP) synthesis and functionalization is proven by size exclusion chromatography (SEC), 1H solution NMR, and 15N solid state NMR spectroscopy. For the first time, BCPs containing primary amines were used for the self-assembly and non-solvent induced phase separation (SNIPS) process for the preparation of isoporous and integral asymmetric membranes. Hexagonally arranged open pores with diameters of 19 nm were obtained as shown by scanning electron microscopy (SEM), atomic force microscopy (AFM), and pH-dependent water flux measurements. Additionally, the primary amine was subjected to convenient postmodification protocols. For instance, (fluorescent) dye molecules could be easily incorporated into the membrane structure, and peptide synthesis on the inner pore wall of the membrane could be accomplished. These novel and tailored porous materials will pave the way to a new generation of BCP membranes containing bio-inspired moieties and functionalities at the interfaces.

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Section: Resultsmentioning

confidence: 99%

Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes

et al. 2019

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Molecular Basis for Differential Recognition of G‐Quadruplex versus Double‐Helix DNA by Bis‐Phenanthroline Metal Complexes

et al. 2016

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1,10-Phenanthroline (Phen) derivatives are attractive ligands to provide metal complexes that are selective for different DNA secondary structures. Herein, we analyze the binding processes of two bis-Phen analogues and their Ni(II) complexes toward double-stranded DNA and telomeric G-quadruplex DNA by calorimetric and spectroscopic techniques. The free ligands can adapt to both DNA arrangements. Conversely, metal ion coordination produces an increase in ligand affinity for the tetrahelical structure, whereas it dramatically decreases binding to double-stranded DNA as a result of distinct binding modes on the two templates. In fact, Ni(II) complexes effectively stack on the G-quadruplex terminals, with an entropic loss counterbalanced by favorable enthalpy changes, whereas they cause a conformational reshaping of the double-helix form with a substantial decrease in the binding free energy. Consistently, no Ni(II) -DNA ionic pair has ever been identified. These results provide a rationale for the selective recognition of distinct DNA arrangements in view of targeted pharmacological applications.

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Chemical speciation and equilibria of some nucleic acid compounds and their iron(III) complexes

Masoud

El-Kaway

Hindawy

et al. 2012

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Protonation equilibria of glycine, 1,10-phenanthroline and 2,2-bipyridyl in ethylene glycol–water mixtures

Cited by 4 publications

References 4 publications

Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes

Amine-Containing Block Copolymers for the Bottom-Up Preparation of Functional Porous Membranes

Molecular Basis for Differential Recognition of G‐Quadruplex versus Double‐Helix DNA by Bis‐Phenanthroline Metal Complexes

Chemical speciation and equilibria of some nucleic acid compounds and their iron(III) complexes

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