Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus

Shi, Hongjuan; Lei, Ying; Wang, Bo; Wang, Zhuo; Xing, Guoqiang; Lv, Hailong; Jiang, Yufeng

doi:10.1016/j.exppara.2016.05.004

Cited by 24 publications

(12 citation statements)

References 42 publications

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“…[43,44] So the injection of protoscolicidal agents into the hydatid cyst to reduce the risk of dissemination of protoscoleces is an integral part of surgical technique. [45] It is worthwhile to mention there is no ideal agent that is both effective and safe has been reported.…”

Section: -Discussionmentioning

confidence: 99%

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa¹

2017

WJPR

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Section: -Discussionmentioning

confidence: 99%

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa¹

2017

WJPR

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“…Shahnazi et al (2017) have shown that incubation of cyst protoscoleces with an extract of 50 and 100 mg/mL of Myrtus communis (Myrtaceae), which has been empirically used in traditional medicine in Iran, led to caspase activation after 4 h at 37°C [43]. Another group of researchers tested the effect of biliary acids on protoscoleces viability in vitro [46]. Using chenodeoxycholic acid at a concentration of 3 mM for 6 days in culture, they showed a 100% mortality rate of protoscoleces of E. granulosus.…”

Section: Regulated Cell Death Of the Echinococcus Parasitementioning

confidence: 99%

Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

2019

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Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.

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“…Spillage of hydatid fluid rich in viable protoscoleces is the leading cause of echinococcosis recurrence; therefore, scolicidal agents are used for inactivating the protoscoleces during surgical procedure. However, these materials have adverse impacts totally [20]. Hypertonic saline is applied as a protoscolicidal material nowadays.…”

Section: Introductionmentioning

confidence: 99%

Scolicidal activity of biosynthesized zinc oxide nanoparticles by Mentha longifolia L. leaves against Echinococcus granulosus protoscolices

et al. 2021

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Cystic echinococcosis is a public health problem in developing countries that practice sheep breeding extensively. In the current study, the protoscolicidal activity of biosynthesized zinc oxide nanoparticles (ZnO NPs) derived from Mentha longifolia L. leaf extracts was investigated. The resultant ZnO NPs were characterized by means of various analytical techniques, such as ultraviolet–visible (UV–Vis) spectrometry, Fourier transform infrared (FT-IR) spectrophotometry, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis. The results showed that the ZnO NP had the highest scolicidal activity at 400 ppm concentration after 150 min of exposure time, showing 100% mortality rate. The treated protoscolices exhibited loss of viability with several morphological alterations. Hence, an easy and effective green synthesis of ZnO NPs, with efficient scolicidal potential, is reported in this study.

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Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus

Cited by 24 publications

References 42 publications

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

Scolicidal activity of biosynthesized zinc oxide nanoparticles by Mentha longifolia L. leaves against Echinococcus granulosus protoscolices

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