Providing a view for toxicity mechanism of tetracycline by analysis of the connections between metabolites and biologic endpoints of wheat

Han, Tao; Wang, Baoshi; Wu, Zhenzhen; Dai, Chunying; Zhao, Jinjin; Mi, Zhaorong; Lv, Yang; Zhang, Chan; Miao, Xinyu; Zhou, Junguo; Li, Xinzheng; Sun, Zhiqiang; Yang, Jiancheng; Zhai, Weiyi; Zheng, Fuxin; Chen, Zhenyang; Zhang, Bo

doi:10.1016/j.ecoenv.2021.111998

Cited by 30 publications

(5 citation statements)

References 34 publications

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“…The aerenchyma structure of M. aquaticum with stem and root connecting is of great ability to absorb nutrients in water. No matter under single CTC/ OTC or combined treatments, the plant height and RGR decreased signi cantly after 14 D. The toxic effects of tetracyclines on plant growth have been demonstrated (Mathews and Reinhold 2013;Liu et al 2020;Han et al 2021;Li et al 2021). In the experiment, the RGR of M. aquaticumw signi cantly increased with low concentration of CTC (1 mg/L) after 7 D. This phenomenon was often called hormesis, where low concentration of CTC may be used as a plant-speci c nutrient source (Gomes et al 2014;Liu et al 2019).…”

Section: Discussionmentioning

confidence: 97%

Separate and Combined Effects of Chlortetracycline and Oxytetracycline on Growth and Antioxidant Enzymes in Myriophyllum Aquaticum

2021

Preprint

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As two typical tetracyclines, chlortetracycline (CTC) and oxytetracycline (OTC) coexist widely in water. In the experiment, Myriophyllum aquaticum (Vell.) Verdc was exposed to the orthogonal hydroponic environment with the concentrations of CTC and OTC at 1, 10, and 50 mg/L for 7 days (7 D) and 14 days (14 D). The results showed that the plant height, relative growth rates (RGR), and photosynthetic pigment contents of M. aquaticum decreased significantly after 14 D of CTC/ OTC, which was stronger than that after 7 D, and the toxicity of CTC was stronger than OTC. The combined toxicity of the two on the RGR and total chlorophyll content was mainly synergistic or additive after 7 D. After 14 D, the interaction changed to antagonism or addition, and the response of total chlorophyll content was more obvious than that of RGR. After 7 D of combined treatments, the malondialdehyde (MDA) content decreased significantly, superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) activities responded to different combined concentrations, respectively, and CAT was the main protective enzyme of M. aquaticum. After 14 D of combined treatments, the hydrogen peroxide (H2O2) content increased significantly, the MDA content increased first and then decreased, and POD was the main protective enzyme among the three antioxidant enzymes. Overall, this study provided the first insight into the single and combined toxicity of CTC and OTC on the growth and physiology of M. aquaticum at different time periods, revealing the reversal of the combined toxicity with time of exposure.

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Section: Discussionmentioning

confidence: 97%

Separate and Combined Effects of Chlortetracycline and Oxytetracycline on Growth and Antioxidant Enzymes in Myriophyllum Aquaticum

2021

Preprint

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“…48 Another reason may be that TC inhibits amino acid metabolism pathways, which could affect root growth. 8 A previous report demonstrated that exposure to a high Environmental Science: Nano Paper concentration (10-300 mg L −1 ) of TC could significantly inhibit cell mitotic division in wheat, inhibiting seedling growth. 49 The PS NP-only treatment showed a similar change in the biomass to that of the TC treatments.…”

Section: Discussionmentioning

confidence: 99%

“…7 For example, TC can affect amino acid metabolism, reduce cell permeability, and increase the reactive oxygen species (ROS) and malondialdehyde (MDA) levels in wheat tissues. 8 Liu et al 9 found that pak choi ( Brassica campestris L. ssp. chinensis ) can take up TC, and when the TC-containing part of pak choi is eaten by humans, it may induce oxidative stress, liver injury, mitochondrial cristae and rough endoplasmic reticulum swelling, and early apoptosis in liver cells.…”

Section: Introductionmentioning

confidence: 99%

Response of wheat (Triticum aestivum L. cv.) seedlings to combined effects of polystyrene nanoparticles and tetracycline

Gao

Bai

Liu

et al. 2023

Environ. Sci.: Nano

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“…In addition to the accumulation of sugars and polyols, up- and down-regulation of amino acid metabolism arise in response to environmental stresses ( Han et al, 2019 , 2021 ). The three aromatic amino acids (tryptophan, phenylalanine and tyrosine) are synthesized via the shikimate pathway and serve as precursors for wide-ranging secondary metabolites, such as indole acetate, glycosides and terpenoids ( Less and Galili, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Combining Metabolic Analysis With Biological Endpoints Provides a View Into the Drought Resistance Mechanism of Carex breviculmis

Liu

et al. 2022

Front. Plant Sci.

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Metabolomics is an effective tool to test the response of plants to environmental stress; however, the relationships between metabolites and biological endpoints remained obscure in response to drought stress. Carex breviculmis is widely used in forage production, turf management, and landscape application and it is particularly resistant to drought stress. We investigated the metabolomic responses of C. breviculmis to drought stress by imposing a 22-day natural soil water loss. The results showed that water-deficit restrained plant growth, reducing plant height, leaf fresh weight, and total weight, however, increasing soluble protein content and malondialdehyde content. In total, 129 differential metabolites in the leaves were detected between drought and control using the Ultrahigh Performance Liquid Chromatography-Mass Spectrometer (UPLC-MS) method. Drought enhanced most of the primary and secondary metabolites in the differential metabolites. Almost all the sugars, amino acids, organic acids, phytohormones, nucleotides, phenylpropanoids and polyketides in the differential metabolites were negatively correlated with plant height and leaf fresh weight, while they were positively correlated with soluble protein content and malondialdehyde content. Metabolic pathway analysis showed that drought stress significantly affected aminoacyl-tRNA biosynthesis, TCA cycling, starch and sucrose metabolism. Our study is the first statement on metabolomic responses to drought stress in the drought-enduring plant C. breviculmis. According to the result, the coordination between diverse metabolic pathways in C. breviculmis enables the plant to adapt to a drought environment. This study will provide a systematic framework for explaining the metabolic plasticity and drought tolerance mechanisms of C. breviculmis under drought stress.

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Providing a view for toxicity mechanism of tetracycline by analysis of the connections between metabolites and biologic endpoints of wheat

Cited by 30 publications

References 34 publications

Separate and Combined Effects of Chlortetracycline and Oxytetracycline on Growth and Antioxidant Enzymes in Myriophyllum Aquaticum

Separate and Combined Effects of Chlortetracycline and Oxytetracycline on Growth and Antioxidant Enzymes in Myriophyllum Aquaticum

Response of wheat (Triticum aestivum L. cv.) seedlings to combined effects of polystyrene nanoparticles and tetracycline

Combining Metabolic Analysis With Biological Endpoints Provides a View Into the Drought Resistance Mechanism of Carex breviculmis

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