Provision of long-term monitoring and late effects services following adult allogeneic haematopoietic stem cell transplant: a survey of UK NHS-based programmes

Abstract

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Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

“…Recent FACT-JACIE standards have incorporated longterm follow-up strategies between specialist transplant centers and local health-care services. Given the long time horizons, this will require support in planning and resources s r a e y 5 r a e y 1 s y a d 0 0 1 s y a d 0 3 s t n e i t a P 0 3 + y a d t a e v i l a s t n e i t a P s t n e i t a p l l A 1 + r a e y t a e v i l a s t n e i t a P 0 0 1 + y a d t a e v i l by public health bodies [27][28][29]. Furthermore, in the era of precision medicine and targeted therapies, HSCT has to provide best outcome regarding overall survival, quality of life and costs compared to any other treatment strategy [16].…”

ASBMT Practice Guidelines Committee Survey on Long-Term Follow-Up Clinics for Hematopoietic Cell Transplant Survivors

“…Other organizations and societies like the Institute of Medicine [4], American Society of Clinical Oncology [5], American Cancer Society [6], and National Institutes of Health BMT Late Effects Initiative [7] have recognized the value of a systematic process for lifelong follow-up of survivors. Given the complexities of HCT survivorship and late effects, systematic lifelong follow-up for HCT survivors can perhaps be achieved via a survivorship or long-term follow-up (LTFU) clinic [8,9].…”

“…Preventive guidelines for surveillance and management of late effects have been established [10], and recently the National Institutes of Health Late Effects Initiative has made recommendations for healthcare delivery for HCT survivors [11]. However, guidance on how to implement recommendations is an important unmet need [12,13]. To advance this nascent area of LTFU, the American Society of Blood and Marrow Transplantation (ASBMT) leadership recognized the importance of developing LTFU guidelines and tasked the Practice Guideline Committee with formulating recommendations for an optimal LTFU clinic based on current state of the art data.…”

Late Effects and Long-Term Follow-Up

“…There are clear guidelines around screening requirements (Majhail et al 2012) but little direction on how these might best be implemented in a late effects (LE) service. A survey of UK transplant centres identified that all had a LE service and most had a standard operating procedure outlining its process but identified wide variability in almost every aspect of the late effects services (Hamblin et al 2017).…”