Proximal gastric distension modifies ingestion rate in pigs

Lepionka, L.; Malbert, CH; Laplace, J.P.

doi:10.1051/rnd:19970406

Cited by 29 publications

(20 citation statements)

References 12 publications

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“…It was established that retention results from the loss of all afferences, while the concomitant reduced volume of efferences is of little importance. During the past few years, the particular importance of the mechanisms responsible for pylorus function [122,124] and the role of gastric fundus distension in relation with the short-term control of food intake [119] further supported the prominent role of visceral sensitivity. The vagal deafferentation also induced significant changes in the pancreas which exhibited significant reductions in the pancreatic tissue mass and in the various enzyme activities, thus suggesting the importance of intestinal sensitivity for the pancreas [110].…”

Section: Resultsmentioning

confidence: 98%

Forty years of achievement in french research on digestive physiology in the pig

Laplace¹,

Aumaı̂tre²,

Rérat³

2001

Reprod. Nutr. Dev.

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-The contribution of the research group set up by Rérat in the early 1960s in Jouy-en-Josas, and then expanded to Rennes, is summarised. As digestive processes are a major key to the nutritional status of monogastric animals, original methodologies based on advanced experimental surgery were developed in the pig to quantify the digestion and absorption yield, to know their factors of variation, and to understand their physiological and nutritional consequences. The group also extended its expertise to the control of food intake, the role of the nervous system and regulatory peptides, and several biomedical gut-related topics. pig / digestion / absorption / neurohumoral regulation / adaptationRésumé -Réalisations et succès de la recherche française : quarante ans de physiologie digestive chez le porc. Dès le début des années 60, un groupe de recherches a été constitué à l'initiative de A. Rérat à Jouy-en-Josas pour étudier divers aspects de la physiologie digestive chez le porc. Leur exploration a fourni des clés essentielles pour la maîtrise du statut nutritionnel chez cette espèce monogastrique, et un instrument d'amélioration de la production porcine. Ce groupe s'est élargi au fil des années et a même essaimé dans les années 80, notamment à Rennes. Il a apporté une contribution essentielle par le développement de méthodologies nouvelles généralement basées sur une chirurgie expérimentale très élaborée. Ces approches ont fourni de nombreux travaux originaux qui ont permis de décrire les processus de digestion (motricité, transit, sécrétions, hydrolyses enzymatiques

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Section: Resultsmentioning

confidence: 98%

Forty years of achievement in french research on digestive physiology in the pig

Laplace¹,

Aumaı̂tre²,

Rérat³

2001

Reprod. Nutr. Dev.

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“…The evolution of food ingestion (g/kg body weight 0.75 ) and ingestion speed (g/min/kg body weight 0.75 ) were automatically extracted using software developed in our laboratory, according to the criteria described by Lepionka et al. (21). For the sake of reading and interpretation, results were presented as kcal/kg of live body weight.…”

Section: Methodsmentioning

confidence: 99%

“…For the sake of reading and interpretation, results were presented as kcal ⁄ kg of live body weight. The initial and final speed of ingestion recorded during the first and last 10 min of the meal were also computed as satiation indicators (21).…”

Section: Recording Of Eating Patternmentioning

confidence: 99%

Brain Processing of Duodenal and Portal Glucose Sensing

Boubaker

Val‐Laillet

Guérin

et al. 2012

J Neuroendocrinology

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Peripheral and central glucose sensing play a major role in the regulation of food intake. Peripheral sensing occurs at duodenal and portal levels, although the importance of these sensing sites is still controversial. The present study aimed to compare the respective influence of these sensing pathways on the eating patterns; plasma concentrations of glucose, insulin and glucagon-like peptide-1 (GLP-1); and brain activity in juvenile pigs. In Experiment 1, we characterised the changes in the microstructure as a result of a 30-min meal in eight conscious animals after duodenal or portal glucose infusion in comparison with saline infusion. In Experiment 2, glucose, insulin and GLP-1 plasma concentrations were measured during 2 h after duodenal or portal glucose infusions in four anaesthetised animals. In Experiment 3, single photon emission computed tomography brain imaging was performed in five anaesthetised animals receiving duodenal or portal glucose or saline infusions. Both duodenal and portal glucose decreased the amount of food consumed, as well as the ingestion speed, although this effect appeared earlier with the portal infusion. Significant differences of glucose and GLP-1 plasma concentrations between treatments were found at the moment of brain imaging. Both duodenal and portal glucose infusions activated the dorsolateral prefrontal cortex and primary somatosensory cortex. Only duodenal glucose infusion was able to induce activation of the prepyriform area, orbitofrontal cortex, caudate and putamen, as well as deactivation of the anterior prefrontal cortex and anterior entorhinal cortex, whereas only portal glucose infusion induced a significant activation of the insular cortex. We demonstrated that duodenal and portal glucose infusions led to the modulation of brain areas that are known to regulate eating behaviour, which probably explains the decrease of food intake after both stimulations. These stimulation pathways induced specific systemic and central responses, suggesting that different brain processing matrices are involved.

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“…A slower passage rate may reduce feed intake (Boudry et al, 2004) probably due to distension of the GIT wall (Lepionka et al, 1997). Dietary fibre may also increase the contractile activity in the gut and accelerate digesta passage (Low, 1990).…”

Section: Introductionmentioning

confidence: 99%