Proximal Humerus Fracture Rehabilitation

Hodgson, Steve A.

doi:10.1097/01.blo.0000194677.02506.45

Cited by 137 publications

(50 citation statements)

References 263 publications

(394 reference statements)

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“…[109][110][111] (ii) Graft degradation. Bone grafts made of metals, ceramics and polymers may degrade in vivo by corrosion, [112][113][114][115][116][117][118] resorption [119][120][121][122][123] and hydrolysis [124][125][126][127][128] processes, respectively. Natural polymer may also be degraded by enzymatic reactions.…”

Section: Essential Properties Of Artificial Bone Graftsmentioning

confidence: 99%

“…Degradation is strongly influenced by the surrounding environment, and in turn degradation products may induce local and systemic host responses. [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128] (iii) Local host response. Successively to an injury/loss and graft implantation, healing mechanisms are activated by the host to restore bone functionality.…”

Section: Essential Properties Of Artificial Bone Graftsmentioning

confidence: 99%

See 1 more Smart Citation

From natural bone grafts to tissue engineering therapeutics: Brainstorming on pharmaceutical formulative requirements and challenges

Baroli

2009

Journal of Pharmaceutical Sciences

172

130

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Section: Essential Properties Of Artificial Bone Graftsmentioning

confidence: 99%

Section: Essential Properties Of Artificial Bone Graftsmentioning

confidence: 99%

From natural bone grafts to tissue engineering therapeutics: Brainstorming on pharmaceutical formulative requirements and challenges

Baroli

2009

Journal of Pharmaceutical Sciences

172

130

View full text Add to dashboard Cite

“…Depending on the graft materials, various mechanisms such as corrosion, resorption, hydrolysis and enzymatic reactions are involved during in vivo degradation [53][54][55].…”

Section: Essential Properties Of Artificial Bone Graftsmentioning

confidence: 99%

Nanocomposites and bone regeneration

et al. 2011

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This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/ healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

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“…In the last few years considerable work has been devoted to develop threedimensional (3D) porous scaffolds from novel biocompatible and biodegradable polymeric materials for the repair, restoration, and regeneration of various tissues, such as skin, ligament, tendon, and bone Kumbar et al, 2008;Laurencin et al, 2006). The synthetic polymers polylactide (PLA), polyglycolide (PGA), poly(lactide-co-glycolide acid) (PLAGA), polycaprolactone, polyanhydrides, and polyphosphazenes have attracted great attention as biomaterials for tissue engineering scaffolding applications (Allcock, 2006;Langer et al, 2004;Levenberg and Langer, 2004;Nair et al, 2006a).…”

Section: Introductionmentioning

confidence: 99%