Proximal renal tubular acidosis with primary Fanconi syndrome

Abstract

Renal tubular acidosis (RTA) is associated with normal or near normal glomerular filtration rate. Proximal RTA is associated with impaired bicarbonate reabsorption. This is manifested as bicarbonate wastage in the urine, and this reflects the defect in proximal tubular transport. Osteopenia or full-blown rickets may develop. Type 2 RTA is rare and occurs in association with conditions such as Fanconi syndrome. This is manifested as glycosuria, aminoaciduria, phosphate wasting and mild proteinuria. The basis of therapy is the continuous administration of appropriate amounts of alkali in the form of either bicarbonate or citrate, as well as the treatment of the cause.

Role of Bee Pollen and Silymarin in Amelioration of Proximal Renal Tubular Acidosis Caused by Cisplatin

“…Renal tubular acidosis (RTA) is a disorder in the acid-base balance in which the kidney loses its ability to excrete enough acid or reabsorb enough bicarbonate (HCO3 -) resulting in metabolic acidosis (Soleimani and Rastegar, 2016). There are four types of RTA; distal RTA (Type 1), proximal RTA (Type 2), combined proximal and distal RTA (Type 3) and hyperkalemic RTA (Type 4) (Philip and Jacob, 2018). In type 2 RTA, most bicarbonate ions are lost in urine due to the inability of proximal tubule to reabsorb them from the glomerular filtrate (Yaxley and Pirrone, 2016).…”