Pruritus‐associated response mediated by cutaneous histamine H<sub>3</sub> receptors

Sugimoto, Yukihiko; Iba, Yoshinori; Nakamura, Yuka; Kayasuga, Ryoji; Kamei, Chiaki

doi:10.1111/j.1365-2222.2004.01876.x

Cited by 67 publications

(37 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…H 3 R antagonists have been reported to produce pruritus-like effects in mice, possibly mediated by C fibers (Schmelz et al, 1997;Hossen et al, 2003;Sugimoto et al, 2004). Because H 3 R-LI is present on keratinocytes but not on epidermal endings, the former may participate in these effects of H 3 R antagonists.…”

Section: Functional Roles For the H 3 Rmentioning

confidence: 99%

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Cannon

Chazot

Hann

et al. 2007

Pain

View full text Add to dashboard Cite

Activation of histamine H 3 receptors (H 3 Rs) reduces inflammation and nociception, but the existence of H 3 Rs on peripheral innervation has never been demonstrated. Here we use antibodies to locate H 3 Rs in whisker pads, hairy and glabrous hind paw skin, dorsal root ganglia (DRGs), and spinal cords of rats, wild-type mice, and H 3 R knockout (H 3 KO) mice. Although H 3 Rs have been hypothesized to be on C and sympathetic fibers, H 3 R-like immunoreactivity (H 3 R-LI) was only detected on presumptive periarterial Aδ fibers and on Aβ fibers that terminated in Meissner's corpuscles and as lanceolate endings around hair follicles. The H 3 R-positive periarterial fibers were thin-caliber and coexpressed immunoreactivity for calcitonin gene-related peptide (CGRP), substance P, acid sensing ion channel 3 and 200kD neurofilament protein (NF). H 3 R-LI was also detected on epidermal keratinocytes and Merkel cells, but not on Merkel endings, C fibers, any other Aδ fibers, or sympathetic fibers. In DRGs, H 3 R-LI was preponderantly on medium to large neurons coexpressing NF-LI and mostly CGRP-LI. In dorsal horn, CGRP-positive fibers with and without H 3 R-LI ramified extensively in lamina II; many of the former formed a plexus in lamina V. Low levels of H 3 R-LI were also present on Aβ fibers penetrating superficial and into deeper laminae. The distribution of H 3 R-LI was similar in rats and wild-type mice, but was eliminated or strongly reduced in Aδ fibers and Aβ fibers, respectively, in H 3 KO mice. Taken with recently published behavioral results, the present findings suggest that periarterial, peptidergic, H 3 R-containing Aδ fibers may be sources of high threshold mechanical nociception.

show abstract

Section: Functional Roles For the H 3 Rmentioning

confidence: 99%

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Cannon

Chazot

Hann

et al. 2007

Pain

View full text Add to dashboard Cite

show abstract

“…However, intriguing data on the H3 receptor seem to contradict the aforementioned histamine-induced itch pathway (Summey and Yosipovitch, 2005); antagonists such as thioperamide and AQ0145 were found to increase significantly the incidence of scratching behaviour in mice (Sugimoto et al, 2004). It is possible that these histamine H3 receptor antagonists block the modulatory role of the presynaptic H3 receptor, thus favouring the release of neuropeptides from sensory endings (Cannon et al, 2007).…”

Section: Histamine and Neurogenic Inflammation In The Skinmentioning

confidence: 99%

The role of histamine in neurogenic inflammation

Rosa

Fantozzi

2013

British J Pharmacology

170

138

View full text Add to dashboard Cite

The term 'neurogenic inflammation' has been adopted to describe the local release of inflammatory mediators, such as substance P and calcitonin gene-related peptide, from neurons. Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. The aim of this review is to summarize the most recent findings on the role of histamine in neurogenic inflammation, with particular regard to nociceptive pain, as well as neurogenic inflammation in the skin, airways and bladder. LINKED ARTICLESThis article is part of a themed issue on Histamine Pharmacology Update. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2013.170.issue-1 Abbreviations CGRP, calcitonin gene-related peptide; ERs, oestrogen receptors; GERD, gastro-oesophageal reflux disease; HDC, histidine decarboxylase; IC, interstitial cystitis; PBS, painful bladder syndrome; SP, substance P; VIP, vasoactive intestinal peptide IntroductionThe term 'neurogenic inflammation' describes the local release of inflammatory mediators, such as substance P (SP) and calcitonin gene-related peptide (CGRP), from afferent neurons. The initial evidence for neurogenic vasodilatation in response to noxious stimuli was obtained in the skin of humans and other mammals (Schmelz and Petersen, 2001), but now it is recognized that neurogenic inflammation also occurs in visceral organs. The inflammatory response evoked by the activation of the sensory nerve fibres, which includes local vasodilatation, plasma extravasation, leukocyte and platelet adhesion, and mast cell degranulation, is brought about by neuropeptides released from the peripheral endings of sensory neurons upon stimulation of the primary sensory terminals. Both SP in neurons and histamine in mast cells have a dual mediator role in neurogenic inflammation (Figure 1). In fact, as demonstrated by Foreman and Jordan (1984), injury causes activation of sensory nerve endings either directly or through the release of histamine from the adjacent mast cells. The action potential generated travels orthodromically to the dorsal horn of the spinal cord and spreads to other branches of the same neurons, which will then release SP from their terminals or varicosities. The released SP, as well as contributing itself to local vasodilatation, induces histamine release from the adjacent mast cells, which produces flare and further activates other sensory nerve endings (Foreman et al., 1983).Neutrophils, whose responsiveness to SP has been repeatedly demonstrated, contribute to the inflammatory soup following neurogenic inflammation. In fact, neutrophils express the SP receptors NK 1, NK2 and NK3, and when stimulated with SP induce the expression of COX-2 and PGE2 release in the nanomolar range (Gallicchio et al., 2008;. Furthermore, SP at micromolar concentrations primes neutrophils, thus en...

show abstract

“…Hypotension, tachycardia, flushing and headache occur through both the H1 and H2 receptors (55), whereas irritation of the skin in the form of itching and nasal congestion can be caused by the activation of H1 and H3 receptors (56,57). The role of histamine can be discussed also as a stimulatory signal for the production of cytokines and the expression of cell adhesion molecules in the latephase of allergic reaction (55,56,58,59).…”

Section: Hi St a M I Ne Re Ce P T Orsmentioning

confidence: 99%

Histamine and Antihistamines / Histamin i antihistamini

Stojkovic¹,

Cekić²,

Ristov³

et al. 2015

Acta Facultatis Medicae Naissensis

View full text Add to dashboard Cite

Pruritus‐associated response mediated by cutaneous histamine H₃ receptors

Abstract: From these results, it may be concluded that H3 receptors are involved in the modulation of pruritus in the skin, and mast cells are not essential in this response. In addition, H3 receptor agonists can be useful as a novel therapeutic approach against pruritus.

Cited by 67 publications

References 23 publications

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

The role of histamine in neurogenic inflammation

Histamine and Antihistamines / Histamin i antihistamini

Contact Info

Product

Resources

About

Pruritus‐associated response mediated by cutaneous histamine H3 receptors

Abstract: From these results, it may be concluded that H3 receptors are involved in the modulation of pruritus in the skin, and mast cells are not essential in this response. In addition, H3 receptor agonists can be useful as a novel therapeutic approach against pruritus.

Cited by 67 publications

References 23 publications

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

The role of histamine in neurogenic inflammation

Histamine and Antihistamines / Histamin i antihistamini

Contact Info

Product

Resources

About

Pruritus‐associated response mediated by cutaneous histamine H₃ receptors