Prussian blue/serum albumin/indocyanine green as a multifunctional nanotheranostic agent for bimodal imaging guided laser mediated combinatorial phototherapy

Sahu, Abhishek; Lee, Jong Hyun; Lee, Hye Gyeong; Jeong, Yong Yeon; Tae, Giyoong

doi:10.1016/j.jconrel.2016.06.031

Cited by 85 publications

(55 citation statements)

References 47 publications

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“…The characteristic peaks of PB were evidently observed at 2085.80 and 1639.16 cm −1 , relating to the bridge vibration of CN stretching region, where the CN groups were bonded to Fe 2+ and Fe 3+ ions. The peak at 495.55 cm −1 was ascribed to the stretching vibration of Fe 2+ CNFe 3+ . Analogous peaks were observed in the spectrum of HMNP‐PB with slight shift to 2089.48, 1634.89, and 496.82 cm −1 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

Zhang

et al. 2017

Adv Healthcare Materials

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The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo. Moreover, the system clearly indicates tumor site with trimodal imaging of magnetic resonance imaging, photoacoustic tomography imaging, and infrared thermal imaging. Furthermore, the system achieves efficient chemo-photothermal combined tumor therapy in vivo with 808 nm laser irradiation for 5 min at 1.2 W cm , revealing the good tumor inhibition effect comparing with those of chemotherapy or photothermal therapy alone. The system is also confirmed to be biocompatible in regard to the mortality rate.

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Section: Resultsmentioning

confidence: 99%

Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

Zhang

et al. 2017

Adv Healthcare Materials

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“…Importantly, this theranostic nanoprobe functionalized by dual modal imaging greatly inhibited lymphatic metastasis of cancer post surgery thereby prolonging animal survival. Other inspiring works based on albumin NPs includes combination of PTT, PDT and imaging in a single nanoplatform by linking ICG and Prussian Blue (PB) . Unlike previous unimodal therapeutic system, this versatile NP is robust and could effectively suppress the tumor growth without recurrence via imaging guided combined therapy.…”

Section: Cyanine Nanoprobes In Cancer Theranosticsmentioning

confidence: 99%

“…Although NIRF imaging has a significant clinical advantage, a combination of NIRF imaging with other state‐of‐the‐art medical imaging modalities is desirable in cancer theranostic . Many multimodal imaging platforms rely on the combination of NIRF probes with magnetic resonance (MR) imaging to avail clinical benefit from combined molecular and anatomical details confined in a single nanoplatform . Although MR imaging is an excellent imaging technique equipped with good spatial resoultion, it suffers from limited sensitivity.…”

Section: Cyanine Nanoprobes In Image Guided Cancer Theranosticsmentioning

confidence: 99%

“…Nevertheless, the exceptional spatial resolution of MRI coupled with the high sensitivity NIRF imaging is a great complement to each other in cancer diagnosis and therapy. For instance, a multifunctional theranostic nanomedicine combining ICG and PB in a single nanoplatform was designed to provide dual mode MR and NIRF image‐guided combined PDT and PTT . This multifunctional NP comprising of clinically approved material demonstrated high tumor accumulation in vivo analyzed by NIRF and T1‐weighted MR bimodal imaging.…”

Section: Cyanine Nanoprobes In Image Guided Cancer Theranosticsmentioning

confidence: 99%

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Cyanine based Nanoprobes for Cancer Theranostics

Bhattarai

Dai

2017

Adv Healthcare Materials

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Cyanine dyes are greatly accredited in the development of non‐invasive therapy that can “see” and “treat” tumor cells via imaging, photothermal and photodynamic treatment. However, these dyes suffer from poor pharmacokinetics inducing severe toxicity to normal cells, insufficient accumulation in tumor regions and rapid photobleaching when delivered in free forms. Nanoparticles engineered to encapsulate these compounds and delivering them into tumor regions have increased rapidly, however, so far, these nanoparticles (NPs) have not proved to be so effective to circumvent existing challenges. Newly designed multifunctional smart nanocarriers that can improve phototherapeutic properties of these dyes, co‐encapsulate multiple potent therapeutic compounds, and simultaneously overcome limitations related to tumor recurrence, metastases, limited intracellular uptake, and tumor hypoxia have potential to revolutionize modern paradigm of cancer therapy. Such cyanine based multifunctional nanocarriers integrating imaging and therapy in a single platform can effectively produce better clinical outcomes in cancer treatment. This review briefly summarizes recent advancements of cyanine nanoprobes that are currently used as imaging/phototherapeutic agents in unimodal/bimodal/trimodal cancer theranostics. Finally, we conclude this review by addressing challenges of pre‐existing therapeutic systems and designs adopted to overcome them with a brief insight assimilating future perspective of emerging cyanine‐based NPs in cancer theranostics.

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“…Moreover, irradiation at a single wavelength removes any possible inhomogeneity in the therapeutic stimulus that could arise when using two wavelengths with different penetration depths into biological tissues. Therefore, some composite systems have been designed to deliver PTT/PDT under a single irradiation, including all‐organic nanocomposites, such as ICG‐loaded Prussian Blue NPs, perfluorooctyl bromide (PFOB)‐ICG coloaded micelles (where PFOB can enhance PDT efficiency by modulating tumor hypoxia), and ROS‐generating polymers loaded with dyes, as well as several hybrid organic–inorganic nanostructures. These typically rely on ICG to provide fluorescence contrast and PDT, while the inorganic part of the nanocomposite (Ag, CuS, graphene oxide) enhances the photothermal effect …”

Section: Nanomaterials For Fluorescence‐guided Combination Therapymentioning

confidence: 99%

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Rosal

Jia

Jaque

2018

Adv Funct Materials

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Nanoparticles (NPs) have attracted great attention for cancer diagnosis and therapy thanks to their unique properties that enable specific tumor uptake, image-guided diagnosis, and tumor suppression triggered by one or more therapeutic modalities. Light-activated NPs have gained particular interest as minimally invasive theranostic agents for fluorescence-guided tumor diagnosis and highly selective phototherapy. The most recent advances in the field focus on shifting their spectral operation range to the second biological window (1000-1400 nm), while improving their efficacy, selectivity, and multifunctionality. In the past few years, multiple systems capable of light-triggered tumor diagnosis through fluorescence imaging (and in many cases, other imaging modalities) and subsequent tumor therapy have been synthesized and evaluated in small animal models. This review summarizes the different approaches for in vivo tumor theranostics, highlighting their advantages and limitations, and provides a critical analysis of the current state of the field.

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Prussian blue/serum albumin/indocyanine green as a multifunctional nanotheranostic agent for bimodal imaging guided laser mediated combinatorial phototherapy

Cited by 85 publications

References 47 publications

Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

Cyanine based Nanoprobes for Cancer Theranostics

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

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