Ps 14-58 Comparison of Lisinopril/Amlodipine and Telmisartan/Amlodipine Combinations in the Management of Hypertension in Patients With Metabolic Syndrome

Mamatkulov, Xasan; Usarov, Muzaffar; Ilkhom, Akhmedov; Hojiev, Sarvar; Manzura, Uzoqova; Davron, Yakhshiboev; Dadaev, Sarvar

doi:10.1097/01.hjh.0000501179.25529.85

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“…Lisinopril is recommended for control of hypertension and congestive heart failure and improving survival after heart attack (Trachtman et al, ). Determination of lisinopril in plasma is essential for conducting pharmacokinetic, bioavailability, bioequivalence, dose–response and therapeutic drug monitoring studies (Loftsson, ; Mamatkulov et al, ; Sukalo et al, ). After oral administration, lisinopril is absorbed by the small intestine and eliminated primarily through glomerular filtration without significant metabolism (Brayfield, ).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a high‐performance liquid chromatography method for determination of lisinopril in human plasma by magnetic solid‐phase extraction and pre‐column derivatization

Rastkari

Ahmadkhaniha

2017

Biomedical Chromatography

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A sensitive, reliable and simple HPLC method was developed for the determination of lisinopril in human plasma. The method consists of extraction and clean-up steps based on magnetic solid-phase extraction and pre-column derivatization with a fluorescent reagent. The mobile phase consisted of a mixture of methanol-sodium dihydrogen phosphate (pH 3.0; 0.005 m; 75:25, v/v). The flow rate was set at 0.7 mL/min. Fluorescence detection was performed at 470nm excitation and 530nm emission wavelengths. Total chromatography run time was 5 min. The average extraction recovery of lisinopril and fluvoxamine (internal standard) was ≥82.8%. The limits of detection and quantification were determined as 1 and 3 ng/mL respectively. The method exhibited a linear calibration line over the concentration range of 3-1000 ng/mL with coefficient of determination (r ) of ≥0.98. The within-run and between-run precisions were satisfactory with values of CV of 1.8-12.8% (accuracy from 99.2 to 94.7%) and 2.4-13.7% (accuracy from 99.5 to 92.2%), respectively. These developments led to considerable improvement in method sensitivity and reliability. The method was validated according to the US Food and Drug Administration guidelines. Therefore, it can be considered as a suitable method for determination of lisinopril in plasma samples.

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Section: Introductionmentioning

confidence: 99%