Pseudo-four-component synthesis of 5-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-substituted 5H-chromeno[2,3-b]pyridines and estimation of its affinity to sirtuin 2

Abstract

Multicomponent reactions (MCRs) are masterpieces of synthetic efficiency and reaction design which allow the rapid generation of complex molecules with biologically relevant scaffold fragments. A new pseudo-fourcomponent, one-pot synthetic scheme yielding 5-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-substituted 5Hchromeno[2,3-b]-pyridines in 40-97% yields is reported. This 'one-pot' process opens an efficient and convenient way to substituted 5H-chromeno[2,3-b]pyridines, which are promising compounds for biomedical applications. Molecular docking studies of the synthesized 5H-chromeno[2,3-b]pyridines were carried out to identify their relationship with the binding pockets of sirtuin 2 (SIRT2).