Pseudo-outbreak of Mycobacterium gordonae associated with water from refrigerated fountains

Lalande, V.; Barbut, Frédéric; Varnerot, A.; Febvre, M.; Nesa, Didier; Wadel, S.; Vincent, Virginia; Petit, J. C.

doi:10.1053/jhin.2000.0929

Cited by 43 publications

(29 citation statements)

References 12 publications

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“…In this validation study, this assay accurately detected all clinically significant organisms and consistently distinguished M. tuberculosis from NTM. It had a lower sensitivity for the detection of M. gordonae, but this lack of sensitivity is of limited clinical consequence, since this organism is usually a laboratory contaminant (2,7,14). The only discordant results for organisms initially characterized by growth characteristics and biochemical reactions were seen with the M. abscessus/M.…”

Section: Discussionmentioning

confidence: 99%

Detection and Differentiation of Mycobacterium tuberculosis and Nontuberculous Mycobacterial Isolates by Real-Time PCR

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Detection and Differentiation of Mycobacterium tuberculosis and Nontuberculous Mycobacterial Isolates by Real-Time PCR

et al. 2003

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“…This method has been applied, with different degrees of success, to both slow-growing NTM, including M. kansasii (164)(165)(166), the MAC (167), M. avium subsp. paratuberculosis (168), M. gordonae (169), and M. haemophilum (170), and rapidly growing mycobacteria, such as M. fortuitum (171)(172)(173), M. chelonae (174), and M. abscessus (92,174). PFGE has also been used as a confirmatory method for the typing of M. abscessus, M. massiliense, and M. bolletii already genotyped by repetitivesequence-based PCR (rep-PCR) (175).…”

Section: Methods Based On Nonrepetitive Sequencesmentioning

confidence: 99%

Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria

et al. 2016

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SUMMARYMolecular typing has revolutionized epidemiological studies of infectious diseases, including those of a mycobacterial etiology. With the advent of fingerprinting techniques, many traditional concepts regarding transmission, infectivity, or pathogenicity of mycobacterial bacilli have been revisited, and their conventional interpretations have been challenged. Since the mid-1990s, when the first typing methods were introduced, a plethora of other modalities have been proposed. So-called molecular epidemiology has become an essential subdiscipline of modern mycobacteriology. It serves as a resource for understanding the key issues in the epidemiology of tuberculosis and other mycobacterial diseases. Among these issues are disclosing sources of infection, quantifying recent transmission, identifying transmission links, discerning reinfection from relapse, tracking the geographic distribution and clonal expansion of specific strains, and exploring the genetic mechanisms underlying specific phenotypic traits, including virulence, organ tropism, transmissibility, or drug resistance. Since genotyping continues to unravel the biology of mycobacteria, it offers enormous promise in the fight against and prevention of the diseases caused by these pathogens. In this review, molecular typing methods forMycobacterium tuberculosisand nontuberculous mycobacteria elaborated over the last 2 decades are summarized. The relevance of these methods to the epidemiological investigation, diagnosis, evolution, and control of mycobacterial diseases is discussed.

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“…M. gordonae is a nontuberculous mycobacterium that exists not only in nature, but also in medical facilities. It has been found in bronchoscopes [6], tap water [7], and refrigerated water [8], all of which are in frequent contact with patients. Therefore, M. gordonae is often handled as ordinary contamination.…”

Section: Discussionmentioning

confidence: 99%

Repeated acute kidney injury associated with Mycobacterium gordonae infection

et al. 2014

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Mycobacterium gordonae is a nontuberculous mycobacterium widely distributed in the environment. Although M. gordonae is not usually pathogenic and glomerular lesions due to M. gordonae are very rare, infection has been reported in both immunocompromised patients and healthy persons. We report a case of acute kidney injury (AKI) in which M. gordonae was ultimately identified as the cause. A 70-year-old man was admitted to our hospital because of fever, polyarthritis, and AKI. He was a hepatitis B virus carrier, suffered from diabetes, and had a past history of erysipelas. No causative bacteria were identified, but coexisting infection was suspected. The patient experienced remission with antibiotic therapy, but the same symptoms recurred eight times. Blood polymerase chain reaction was performed during the 7th recurrence, and M. gordonae was detected. Clarithromycin was initiated, but 2 years after initial hospitalization, the patient died due to M. gordonae infection. In this case, acute kidney injury was a consequence of infection-related glomerulonephritis due to M. gordonae. Mycobacterium is difficult to detect by routine culture methods; therefore, diagnosis remains challenging.

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Pseudo-outbreak of Mycobacterium gordonae associated with water from refrigerated fountains

Cited by 43 publications

References 12 publications

Detection and Differentiation of Mycobacterium tuberculosis and Nontuberculous Mycobacterial Isolates by Real-Time PCR

Detection and Differentiation of Mycobacterium tuberculosis and Nontuberculous Mycobacterial Isolates by Real-Time PCR

Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria

Repeated acute kidney injury associated with Mycobacterium gordonae infection

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