Pseudocholinesterase Deficiency – Is Succinylcholine Still Needed to Facilitate Endotracheal Intubation?

Kurnutala, Lakshmi N; Rugnath, Nickhil

doi:10.7759/cureus.10721

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…The sensitivity of BChE to organophosphorus poisons, therapeutic effects of BChE on drug addicts [4,6], and the susceptibility to high-fat diet-induced obesity in BChE knockout (KO) mice [7,8] were reported. A decrease in BChE levels results in an increased sensitivity to anesthetic agents (e.g., succinylcholine and mivacurium) [9]. Acetylcholine (Ach), a substrate of ChE, exhibits a vital role in cognitive functions' neuromodulation [10].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

Liu

Cao

Yang

et al. 2021

Biology

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Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE knockout (KO) mice and wild-type (WT) mice with orally or intranasal administration of (R)-bambuterol were used to explore the effect of BChE on behavior changes. (R)-bambuterol is a specific and reversible inhibitor of BChE. The behavior changes were evaluated and compared among 3–10 month old mice. Our finding showed that BChE KO and (R)-bambuterol administration enhanced episodic memory, including fear conditioning memory and fear extinction memory in fear conditioning and fear extinction test. BChE KO and (R)-bambuterol administered mice rescued age-related spatial memory and general activity in the water maze test and open field test. The brain metabolomics were imaged using a desorption electrospray ionization mass spectrometry imaging (DESI-MSI). The image of DESI-MS demonstrated that glutamine content increased in the brain of BChE KO mice. In conclusion, this study found that inhibition of BChE ameliorated episodic and spatial memories. This study also suggested that (R)-bambuterol as a BChE inhibitor has the potential application in the treatment of post-traumatic stress disorder (PTSD) and early cognitive decline.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

Liu

Cao

Yang

et al. 2021

Biology

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Development of Prolonged Apnoea in a Suxamethonium-Naïve Patient During Electroconvulsive Therapy: A Case Report

Bulut,

Papanna,

Ahmed

et al. 2024

Cureus

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Suxamethonium is commonly used as a muscle relaxant during electroconvulsive therapy (ECT). Prolonged apnoea associated with suxamethonium, mostly caused by pseudocholinesterase deficiency, is rare, but it can sometimes pose a great challenge in managing emergency situations due to patients’ inability to breathe; occasionally, it can result in serious complications, including death. We report a case of a young male who had no prior exposure to suxamethonium and developed prolonged apnoea after induction with it. There was no record of any sensitivity or adverse reactions to any drugs for this patient or his family. ECT is a well-known treatment for many psychiatric disorders when other treatments are ineffective. This case emphasizes the need for a comprehensive pre-procedural assessment, careful consideration, and the gathering of crucial information about potential sensitivities and adverse reactions associated with medications commonly used during the ECT procedure, especially when administering these medications for the first time.

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Pseudocholinesterase Deficiency – Is Succinylcholine Still Needed to Facilitate Endotracheal Intubation?

Cited by 2 publications

References 13 publications

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

Development of Prolonged Apnoea in a Suxamethonium-Naïve Patient During Electroconvulsive Therapy: A Case Report

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