Pseudoexfoliation syndrome and aneurysms of the abdominal aorta

Schumacher, Susanne; Schlötzer‐Schrehardt, Ursula; Martus, Peter; Lang, Werner; Naumann, G. O. H.

doi:10.1016/s0140-6736(00)03645-x

Cited by 186 publications

(160 citation statements)

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“…[3][4][5] It has been associated with many cardiovascular and cerebrovascular diseases 2 and recent studies have suggested it as a marker of systemic vascular diseases. 6,7 YKL-40 is a recently discovered proinflammatory protein that has been demonstrated to have a role in the pathogenesis of endothelial dysfunction and atherosclerosis. 8 Increased serum YKL-40 concentration has been found to be associated with cardiovascular morbidity.…”

Section: Introductionmentioning

confidence: 99%

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Türkyılmaz

Oner

Kırbaş

et al. 2013

Eye

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Purpose To evaluate serum levels of YKL-40 in patients with pseudoexfoliation syndrome (PEX) in comparison with those of age-and sex-matched healthy subjects. Methods Forty patients with PEX (PEX group) and 40 age-and sex-matched control subjects (control group) were enrolled in the study. An enzyme immunoassay method using the commercially available test MicroVue YKL-40 was used to measure serum YKL-40 concentration. Systolic and diastolic blood pressures, serum levels of high sensitivity C-reactive protein (hsCRP), total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides were also examined. Results The mean age was 54.4 ± 7.6 (ranging 41-65) years in each group. The mean serum YKL-40 level of the PEX group was significantly higher than that of the control group (Po0.001). In addition, the mean serum HsCRP, total cholesterol, LDL, and triglycerides levels were significantly higher, and mean serum HDL level was significantly lower in the PEX group than in the control group (all Po0.001, excluding both P ¼ 0.002 for triglycerides and HDL levels). Further, the mean systolic and diastolic blood pressures were significantly higher in the PEX group than in the control group (P 1 ¼ 0.001 and P 2 ¼ 0.01, respectively). Conclusion We have shown a relationship between PEX and elevated serum levels of YKL-40. We imply that a better understanding of the role of YKL-40 in the pathogenesis of endothelial dysfunction and atherosclerosis is necessary to develop new therapies for preventing or treating PEX. Further studies are warranted to clarify the clinical relevance of these findings.

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Section: Introductionmentioning

confidence: 99%

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Türkyılmaz

Oner

Kırbaş

et al. 2013

Eye

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“…Um estudo caso-controle encontrou associação estatisticamente significante entre SPEX e aneurisma de aorta abdominal (12) , detectando a presença de material exfoliativo em 24 (44%) dos 55 pacientes com aneurisma e em 8 (20%) dos 41 pacientes com oclusão de artéria carótida (p = 0,016). O exame histopatológico de cinco amostras de parede aórtica, obtidas de doadores de órgãos com SPEX apresentavam material exfoliativo no tecido conectivo subendotelial e da camada adventícia, fibrose e elastose da túnica íntima.…”

Section: Discussionunclassified

“…Um estudo que avaliou os tipos de glaucoma de uma população seguida no Hospital das Clínicas da UNICAMP encontrou uma prevalência de 1,3% de glaucoma pseudo-exfoliativo (16) . Tal prevalência é inferior à encontrada em outros relatos (6,12,17) , provavelmente devido à composição étnica brasileira. A baixa prevalência de SPEX no nosso meio justificaria a necessidade de uma amostra maior de pacientes para que pudéssemos melhor analisar a diferença entre os grupos.…”

Section: Discussionunclassified

“…Uma associação entre aneurismas de aorta abdominal e SPEX foi sugerida (12) , que também estaria associada com eventos cardiovasculares (6) . Alterações histopatológicas da parede da aorta abdominal em pacientes com SPEX poderiam predispor estes pacientes ao desenvolvimento de aneurismas (12) .…”

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“…Alterações histopatológicas da parede da aorta abdominal em pacientes com SPEX poderiam predispor estes pacientes ao desenvolvimento de aneurismas (12) . SPEX, por essa razão, poderia ser um importante marcador Análise da correlação entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal Objetivo: Examinar a correlação sugerida entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal.…”

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Análise da correlação entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal

Filho¹,

Araújo²,

Costa³

et al. 2004

Arq. Bras. Oftalmol.

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0,05). Dois dos 65 pacientes com aneurisma de aorta e um dos 51 controles apresentaram síndrome de pseudo-exfoliação (p = 1,00). CONCLUSÃO: A prevalência de síndrome de pseudo-exfoliação em pacientes operados por aneurisma de aorta abdominal e em pacientes com aterosclerose periférica foi similar. Este achado não confirma a associação proposta entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal.]]>

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Risk for Exfoliation Syndrome in Women With Pelvic Organ Prolapse

et al. 2016

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IMPORTANCE Exfoliation syndrome, an inherited systemic disorder of elastin and extracellular matrix (ECM), is associated with the LOXL1 gene locus. Pelvic organ prolapse is a common connective tissue disorder that affects women. The presence of an association between exfoliation syndrome (exfoliation of the lens capsule) and pelvic organ prolapse was investigated as part of the Utah Project on Exfoliation Syndrome (UPEXS).OBJECTIVE To examine the association between exfoliation syndrome and pelvic organ prolapse using the Utah Population Database, a comprehensive resource linked to medical records. DESIGN, SETTING, AND PARTICIPANTSA 2-pronged approach was used. In substudy A, a cross-sectional analysis was performed to determine the association between pelvic organ prolapse and exfoliation syndrome in women enrolled in Medicare in Utah from calendar year 1992 to 2009 (n = 132 772). In substudy B, the risk of incident exfoliation syndrome from January 1, 1995, to December 31, 2014, was estimated in a cohort of women aged 30 to 65 years at baseline with a diagnosis of pelvic organ prolapse (n = 5130) compared with birth year-matched women serving as controls who did not have pelvic organ prolapse (n = 15 338). MAIN OUTCOMES AND MEASURES Exfoliation syndrome outcome was defined byInternational Classification of Diseases, Ninth Revision, diagnosis codes for exfoliation syndrome or exfoliation glaucoma (366.11 or 365.52, respectively). In substudy A, odds ratios (ORs) from unconditional logistic regression models were used to estimate the exfoliation syndrome risk in women with pelvic organ prolapse compared with those without pelvic organ prolapse. In substudy B, hazard ratios (HRs) from Cox proportional hazards models were used to estimate incident exfoliation syndrome risk in patients with pelvic organ prolapse (without exfoliation syndrome history) compared with unaffected controls. Models were adjusted for age, years enrolled, parity, and race/ethnicity. RESULTSOf the 132 772 women enrolled in Utah Medicare from 1992 to 2009, the mean [SD] age at the last enrollment was 82.2 [7.7] years. Pelvic organ prolapse was associated with a 1.56-fold increased risk of exfoliation syndrome in Medicare beneficiaries (OR, 1.56; 95% CI, 1.42-1.72) in substudy A. We observed a 48% increased incident risk of exfoliation syndrome in women aged 30 to 65 years at baseline who had a pelvic organ prolapse diagnosis compared with controls during 20 years of follow-up (HR, 1.48; 95% CI, 1.14-1.91). CONCLUSIONS AND RELEVANCEThe diagnosis of exfoliation syndrome was more frequent in women with pelvic organ prolapse in the Utah Population Database, a robust population-based resource, thus supporting an association of exfoliation syndrome with a nonocular systemic condition. Systemic conditions with altered ECM metabolism, such as pelvic organ prolapse, may share common biological pathways with exfoliation syndrome. LOXL1 dysregulation, thought to occur in exfoliation syndrome, may be a contributing factor.

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Pseudoexfoliation syndrome and aneurysms of the abdominal aorta

Cited by 186 publications

References 4 publications

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Análise da correlação entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal

Risk for Exfoliation Syndrome in Women With Pelvic Organ Prolapse

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