In the area of synthetic sensors for flow angle estimation, the present work aims to describe the verification in a relevant environment of a physics-based approach using a dedicated technological demonstrator. The flow angle synthetic solution is based on a model-free, or physics-based, scheme and, therefore, it is applicable to any flying body. The demonstrator also encompasses physical sensors that provide all the necessary inputs to the synthetic sensors to estimate the angle-of-attack and the angle-of-sideslip. The uncertainty budgets of the physical sensors are evaluated to corrupt the flight simulator data with the aim of reproducing a realistic scenario to verify the synthetic sensors. The proposed approach for the flow angle estimation is suitable for modern and future aircraft, such as drones and urban mobility air vehicles. The results presented in this work show that the proposed approach can be effective in relevant scenarios even though some limitations can arise.