Pseudomonas aeruginosa bacteraemia in cancer patients

Krčméry, V.; Koprnova, J.; Gogova, Maria; Grey, E.; Korcova, Jarmila

doi:10.1016/j.jinf.2005.06.004

Cited by 11 publications

(8 citation statements)

References 3 publications

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“…PA infection has been implicated in prolonged hospitalization and shortened lives of cancer patients [7],[22]. Thus, we analyzed the effects of PA infection on tumor metastasis in an animal model using a PAK strain.…”

Section: Resultsmentioning

confidence: 99%

“…Bacterial infection is a critical complication that may lead to prolonged hospitalization of cancer patients [6],[7],[22]. Bacteremia, the presence of viable bacteria circulating in the bloodstream, results in a reduction in the number of lymphocyte subsets [39],[40],[41], which in turn may result in tumor propagation in these patients [42].…”

Section: Discussionmentioning

confidence: 99%

“…PA constitutes the major cause of prolonged hospitalization, severe illness, death, and increased cost for immunocompromised patients. A high mortality rate occurs in patients with underlying disease, such as cystic fibrosis and cancer [6],[7].…”

Section: Introductionmentioning

confidence: 99%

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Pseudomonas aeruginosa Eliminates Natural Killer Cells via Phagocytosis-Induced Apoptosis

et al. 2009

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Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes the relapse of illness in immunocompromised patients, leading to prolonged hospitalization, increased medical expense, and death. In this report, we show that PA invades natural killer (NK) cells and induces phagocytosis-induced cell death (PICD) of lymphocytes. In vivo tumor metastasis was augmented by PA infection, with a significant reduction in NK cell number. Adoptive transfer of NK cells mitigated PA-induced metastasis. Internalization of PA into NK cells was observed by transmission electron microscopy. In addition, PA invaded NK cells via phosphoinositide 3-kinase (PI3K) activation, and the phagocytic event led to caspase 9-dependent apoptosis of NK cells. PA-mediated NK cell apoptosis was dependent on activation of mitogen-activated protein (MAP) kinase and the generation of reactive oxygen species (ROS). These data suggest that the phagocytosis of PA by NK cells is a critical event that affects the relapse of diseases in immunocompromised patients, such as those with cancer, and provides important insights into the interactions between PA and NK cells.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pseudomonas aeruginosa Eliminates Natural Killer Cells via Phagocytosis-Induced Apoptosis

et al. 2009

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“…This can occur in patients with a serious underlying condition such as cancer (Krcmery et al, 2006), AIDS (Meynard et al, 1999), or major burn wounds (Regules et al, 2007), or those with immune suppression from recent surgery or organ transplant (Botha et al, 2006;Defez et al, 2004;Ullah et al). Neonates are also very susceptible to P.…”

Section: Pseudomonas Aeruginosa Disease Associationmentioning

confidence: 99%

Anti-Quorum Sensing Agents from South Florida Medicinal Plants and their Attenuation of Pseudomonas Aeruginosa Pathogenicity

Adonizio¹

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This dissertation, written by Allison L. Adonizio, and entitled Anti-quorum sensing agents from south Florida medicinal plants and their attenuation of Pseudomonas aeruginosa pathogenicity, having been approved in respect to style and intellectual content, is referred to you for judgment.We have read this dissertation and recommend that it be approved. Each plant presented a distinct profile of effect on QS genes and signaling molecules, suggesting varying modes of action. Virulence attenuation was observed with marginal reduction of bacterial growth, suggesting quorum quenching mechanisms unrelated to static or cidal effects. Extracts of these plants were also investigated for their effects on P. aeruginosa killing of the nematode Caenorhabditis elegans. Results were evaluated in both toxin-based and infection-based assays with P. aeruginosa strains PA01 and PA14. _____________________________Overall nematode mortality was reduced 50-90%. There was no indication of host toxicity, suggesting the potential for further development as anti-infectives. Using lowpressure chromatography and HPLC, two stereoisomeric ellagitannins, vescalagin and castalagin were isolated from an aqueous extract of C. erectus. Structures were confirmed via mass spectrometry and NMR spectroscopy. Both ellagitannins were shown to decrease signal production, QS gene expression, and virulence factor production in P.aeruginosa. This study introduces a potentially new therapeutic direction for the treatment of bacterial infections. In addition, this is the first report of vescalagin and castalagin being isolated from C. erectus, and the first report of ellagitannin activity on the QS system.

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“…Pseduomonas aeruginosa resistant strains are commonly found as a secondary infection in immune-compromised patients with cystic fibrosis, COPD, AIDS, Cancer and even among diabetics (Rubin Grandis, Branstetter et al 2004;Krcmery, Koprnova et al 2006;Gomes, Machado et al 2011;Engler, Muhlemann et al 2012;Hogardt and Heesemann 2013) leaving serious blood stream infection with significant mortality and healthcare cost (Weinstein, Towns et al 1997;Wisplinghoff, Seifert et al 2003). The success in establishing P. aeruginosa pathogenecity is largely due to formation of intractable biofilms and secretion of myriads of virulent factors including LasA protease, LasB elastase, pyocyanin, pyoverdin, Type III secretion (T3S) effectors and alginate (Kessler, Safrin et al 1997;Lyczak, Cannon et al 2002;McIver, Kessler et al 2004;Lee, Smith et al 2005;).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Rab5 GTPase activity during Pseudomonas aeruginosa-macrophage interaction

Mustafi¹

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Pseudomonas aeruginosa bacteraemia in cancer patients

Cited by 11 publications

References 3 publications

Pseudomonas aeruginosa Eliminates Natural Killer Cells via Phagocytosis-Induced Apoptosis

Pseudomonas aeruginosa Eliminates Natural Killer Cells via Phagocytosis-Induced Apoptosis

Anti-Quorum Sensing Agents from South Florida Medicinal Plants and their Attenuation of Pseudomonas Aeruginosa Pathogenicity

Regulation of Rab5 GTPase activity during Pseudomonas aeruginosa-macrophage interaction

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