Pseudomonas aeruginosa Quorum Sensing and Biofilm Inhibition

Biofilm Disruption and Virulence Attenuation Effects of Essential Oil From Endemic Algerian Cistus munbyi (Cistaceae) Against Clinical Strains of Pseudomonas aeruginosa

“…[9][10][11] The QS network in P. aeruginosa is therefore dependent on the density of the bacterial population and their ability to communicate with each other and it relies on the production and reception of small diffusible signal molecules mostly N-acyl-homoserine lactone (AHL) molecules. [12][13][14] When these diffusible pheromones reach a critical threshold concentration, they bind to the type "R" transcriptional regulator. The successful linkage of autoinducers to transcriptional regulators activates the expression of "I" target genes associated with pathogenicity, ecological adaptation, control of virulence factors, the formation of biofilms and the development of antibiotic resistance.…”

“…8,15,26 The fourth QS channel recently discovered is the Iqs which utilizes 2-(2-hydroxyphenyl)-thiazole-4-carbaldehyde as its signal molecule and contributes to regulating responses to environmental stress, inhibition of host's cell growth and stimulation of apoptosis. 8,12,26 Other virulence factors are usually regulated by different systems, for example, the Las and Rhl systems are involved in the formation of biofilm. 21 Biofilms are highly structured architecture consisting of microcolonies fixed to a surface and embedded in a self-produced extracellular matrix composed of exopolysaccharides, proteins, nucleic acids and lipids.…”

“…33,35,36 Fixation of P. aeruginosa on surfaces is followed by progression towards a mature biofilm in which microcolonies develop and multiply on surfaces producing extracellular polymer substances (EPS) as a solid structural matrix for better attachement. 12,15 This EPS selfsecreted polymer matrix provides a scaffold and protective barrier to embedded cells against various stresses such as bacteriophages and host immune responses making them able to resist antimicrobial treatments up to 1000 times more than their planktonic counterparts. [37][38][39] Biofilms contribute to chronic infections that are difficult to treat with ordinary antibiotics.…”

“…8,15,26 The fourth QS channel recently discovered is the Iqs which utilizes 2-(2-hydroxyphenyl)-thiazole-4-carbaldehyde as its signal molecule and contributes to regulating responses to environmental stress, inhibition of host's cell growth and stimulation of apoptosis. 8,12,26…”

Systematic Review: Skrining Aktivitas Anti Quorum sensing Tumbuhan Terhadap Pseudomonas aeruginosa

“…Sistem ini umum ditemukan pada bakteri, seperti pada P. aeruginosa, yaitu bakteri yang dikenal memiliki berbagai taktik untuk menghindari efek bakteriosidal dan bakteriostatik antibiotik. Beragam taktik ini menjadi alasan P. aeruginosa menunjukkan fenotip MDR yang artinya bakteri ini resistan terhadap setidaknya tiga atau lebih antibiotik (Adonizio, 2008;Gökalsin et al, 2019;Negara, 2014;Ochoa et al, 2013;Raakhee & Rao, 2014).…”