Pseudomonas paucimobilis peritonitis in patients treated by peritoneal dialysis

Abstract

Pseudomonas paucimobilis has rarely been reported as an opportunistic human pathogen. We report the isolation of this organism in two patients who developed peritonitis during the course of intermittent or continuous ambulatory peritoneal dialysis. The origin of the infection was related to contamination of the dialysate in the first patient but could not be determined in the second case.

Peritoneal Dialysis Related Peritonitis by Sphingomonas Paucimobilis

“…It is an uncommon pathogen for PD-related peritonitis, and clinical outcomes in the cases reported so far have varied, with some cases responding to antibiotic therapy alone (5)(6)(7)(8)(9)(10)(11) whereas others have eventually required catheter removal (approximately 50%) (4,5,(12)(13)(14). Literature about peritonitis and treatment caused by Sphingomonas species in PD patients is very limited ( Table 1).…”

Autoimmune disease triggered by infection with alphaproteobacteria

“…Sphingomonas/Novosphingobium spp. [85,86], preferentially Sphingomonas paucimobilis (formerly Pseudomonas paucimobilis), have been implicated in a variety of communityacquired and nosocomial infections, including bacteremia, catheter-related sepsis, meningitis, peritonitis, pneumonia, cutaneous infections, visceral abscesses, urinary and biliary tract infections, adenitis and diarrheal disease [87][88][89][90][91][92][93][94][95][96][97]. The lack of a typical lipopolysaccharide constituent of the cellular membrane of Sphingomonas/Novosphingobium, accompanied by the deficiency of endotoxin activity, may explain the lack of deaths attributed to this organism [98][99][100].…”

“…Administration of antibiotics resulted in the resolution of infection [87][88][89][90][91][92][93][94][95][96][97]. Nosocomial Novosphingobium infection can be as resistant as Pseudomonas infection, therefore combination therapy of a third-generation cephalosporin and an aminoglycoside is recommended [101].…”

Microbiological aspects of peritonitis associated with continuous ambulatory peritoneal dialysis.

“…The origin may be the skin or a contaminated water bath used to heat the dialysis bag (5). The latter mechanism also operated in the pathogenesis of CAPD peritonitis due to other rare nonfermenters (43,118).…”