Pseudopterygium: Unique Conjunctival Stricture Observed in Japanese White Rabbit

Katsuta, Osamu; Shinomiya, Katsuhiko; Mochizuki, Takaharu; Kikkawa, Chinami; Yoshimi, Miwa; Ikuse, Toshimi

doi:10.1293/tox.21.239

Cited by 7 publications

(4 citation statements)

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“…Comments: Infrequently, the rabbit cornea is progressively covered by hyperplastic conjunctiva around the entire perimeter. Of unknown etiology, the condition appears to be unique to rabbits 222 , 243 , 244 , 245 , 246 , 247 , 248 . Conjunctival hyperplasia can be unilateral or bilateral, and is characterized clinically by a circumferential, nonadherent membranous flap which arises from the perilimbal bulbar conjunctiva and grows centripetally and symmetrically across the anterior corneal surface.…”

Section: Section 16: Special Sensesmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand. asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Section 16: Special Sensesmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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“…A displasia do colágeno tem sido postulada como uma possível causa do crescimento conjuntival desarranjado, resultando em uma folha de tecido conjuntival centrípeto [1]. Outros possíveis fatores abordados como causa dessa afecção são fatores imunológicos, traumas ou condições inflamatórias [3,4,6]. Em contrapartida, no caso relatado, não foi possível afirmar a associação da causa do crescimento conjuntival a qualquer anomalia descrita, preconizando que a etiopatogenia do pseudopterígio permanece desconhecida.…”

Section: Discussionunclassified

“…Além disso, ainda não se sabe porque a conjuntiva se prolifera de forma centrípeta no pseudopterígio [3], já que quando comparado ao pterígio em humanos, o crescimento é de forma triangular, elevado no limbo da córnea, com um ápice localizado na córnea, em que o crescimento tende a se orientar lateralmente, na fissura interpalpebral tanto no canto medial ou lateral [3]. No caso em questão, o crescimento aberrante da membrana teve percurso caracterizado conforme a literatura descreve para a espécie.…”

Section: Discussionunclassified

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Pseudopterygium in a Rabbit - Treatment with Tracolinus

Farencena¹,

Krebs²,

Girondi³

et al. 2022

Acta Scientiae. Vet.

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Background: Pseudopterygium, also known as aberrant conjunctival growth, is poorly described in the literature, although it is known that this abnormality is uncommon and affects dwarf rabbits and their crossbreeds. The etiology of this disease is unknown, but there are hypotheses that the conjunctival growth cause may have its origins in immunological factors, inflammation, traumatic conditions, or cartilage dysplasias. Thus, this study reports the treatment efficacy applied in a rabbit, through the continuous use of tracolimus eye drops, after surgical procedure of conjunctival fold resection, as a way of controlling the pseudopterygium in rabbits.Case: This case report discusses the positive results from the surgical and therapeutic conduct of a clinical case attended by the Ophthalmology and Microsurgical Veterinary Service at the Hospital Veterinário Universitário (HVU) of the UFSM. The patient was a male rabbit, sterilized cunicle, approximately 2-year-old, crossed with a dwarf rabbit. The owner's main complaint was the change in the aspect of the left eye, with progressive worsening in the previous four weeks. In the ophthalmological examination, the animal did not present impaired vision or discomfort, however, a vascularized pink membrane was noted, which consisted of a fold of the bulbar conjunctiva, that grew centripetally and covered 90% of the cornea in 360 degrees. The diagnosis was confirmed through visual inspection and the patient's history. The eye alteration had a characteristic aspect, described as proliferation of the bulbar conjunctiva over the cornea, in a centripetal manner and without signs of inflammation. In addition, other ophthalmological alterations were ruled out during the patient's physical and specific examination. The patient was referred for anesthetic evaluation and, in addition, pre-surgical blood tests were performed, which were normal, according to the expected ranges for the species. Subsequently, the animal was submitted to surgical treatment, which consisted of dividing the exuberant conjunctiva, followed by three radial incisions in equal portions. Next, the conjunctival fold was completely incised to the edge of the limbus, without the need of sutures. Anterior lamellar keratectomy was performed on the portion where the membrane was attached to the cornea. For home care, tobramycin-based eye drops (QID, for 7 days) and 0.02% aqueous tacrolimus eye drops (BID - continuous use) were prescribed. The animal was reevaluated 7, 14, 30, 60, 120 and 180 days after surgical correction, and no recurrence of pseudopterygium was observed during the follow-up period. The prognosis of patients with pseudopterygium is reserved, as it is known that the disease may recur after surgical treatment. Therefore, the continuous use of the chosen immunomodulating eye drops was recommended as well as periodic follow-up of the patient.Discussion: In the current study, it was not possible to increase knowledge regarding about the pseudopterygium etiology. Although the condition is not serious, it can cause partial impairment of vision and chronic discomfort. However, the vision field described in the rabbit in this current case remained unchanged, in accordance with other cases described in the literature. Furthermore, no signs of patient discomfort were detected. Some surgical techniques described in the literature for correction of pseudopterygium, shows membrane’s growth recurrence. The use of immunomodulatory drugs is suggested for relapses controlling. In this study, the tracolimus eye drops efficacy was tested, and presented good results in the patient's evaluations for a long period after surgery. The use of immunomodulators is an option for adjuvant topical treatment for controlling pseudopterygium growth, which, associated with corrective surgical treatment, has shown positive results.Keywords: conjunctiva, aberrant, immunomodulator, treatment, bunny.Título: Pseudopterígio em coelho - tratamento com tracolimusDescritores: conjuntiva, aberrante, imunomodulador, tratamento, coelho.

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Methodologies for Microscopic Characterization of Ocular Toxicity

Teixeira

Render

2013

Methods in Pharmacology and Toxicology

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Pseudopterygium: Unique Conjunctival Stricture Observed in Japanese White Rabbit

Cited by 7 publications

References 3 publications

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

Pseudopterygium in a Rabbit - Treatment with Tracolinus

Methodologies for Microscopic Characterization of Ocular Toxicity

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