2021
DOI: 10.21203/rs.3.rs-603830/v1
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PSMA-Ligand Uptake Can Serve as a Novel Biomarker in Primary Prostate Cancer to Predict Outcome After Radical Prostatectomy

Abstract: BackgroundThe prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is increasingly used for primary prostate cancer staging and the molecular imaging TNM classification (miTNM) standardizes its reporting. We aimed to investigate the potential of PET-imaging to serve as a noninvasive imaging biomarker to predict disease outcome in primary prostate cancer after radical pr… Show more

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“…In a study by Wang et al . [28], that studied 195 patients receiving a 68 Ga‐PSMA‐11‐PET/CT for initial staging before RARP, an association was reported between SUV max and surgical margin status on univariate analysis ( P = 0.04). The SUV max was not found to be an independent variable for surgical margin status when assessed along other imaging parameters such as tumour volume, miN status, miT stage.…”
Section: Discussionmentioning
confidence: 99%
“…In a study by Wang et al . [28], that studied 195 patients receiving a 68 Ga‐PSMA‐11‐PET/CT for initial staging before RARP, an association was reported between SUV max and surgical margin status on univariate analysis ( P = 0.04). The SUV max was not found to be an independent variable for surgical margin status when assessed along other imaging parameters such as tumour volume, miN status, miT stage.…”
Section: Discussionmentioning
confidence: 99%