Psoriasis and Somatostatin in Serum

Geisner, Benedikte; Skavland, Jørn; Marcusson, Jan A.; Johansson, Ӧlle; Elsayed, Said

doi:10.2340/00015555-0261

Cited by 5 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports show an increased concentration of SST in serum of patients with psoriasis and also an increased number of SST-positive dendritic cells in psoriatic lesions compared to healthy skin (28,29). Therefore, SSTR agonists could provide an attractive opportunity for pharmacological intervention of barrier disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, SSTR agonists could provide an attractive opportunity for pharmacological intervention of barrier disorders. Reports show an increased concentration of SST in serum of patients with psoriasis and also an increased number of SST-positive dendritic cells in psoriatic lesions compared to healthy skin (28,29). During treatment of psoriasis with clobetasol propionate and calcipotriol, the number of SST-positive cells is reduced (30).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Somatostatin regulates tight junction function and composition in human keratinocytes

Vockel

Breitenbach

Kreienkamp

et al. 2010

Experimental Dermatology

View full text Add to dashboard Cite

Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in human skin and is present in a subset of Merkel cells and dendritic cells as well as in keratinocytes. We focused further on the somatostatin receptor subtype 3 (SSTR3) and its interacting protein MUPP1, as both were found to be localized at cellular junctions in epidermal keratinocytes. MUPP1 is a component of tight junctions (TJs); these cell-cell junctions contribute to barrier function of the paracellular pathway in cultured keratinocytes. We provide evidence that SSTR3 and MUPP1 interact in primary cultured human keratinocytes at high Ca(2+) conditions. Interestingly, SST, presumably via SSTR3/MUPP1, regulates TJ permeability in cultured keratinocytes. During long-term treatment of human keratinocytes, SST also affects the expression of distinct TJ proteins such as claudin-4. Our data are the first example of a peptide hormone regulating TJ functionality and composition in human keratinocytes, suggesting that control via peptide hormones provides the possibility to regulate the TJ barrier characteristics of the skin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Somatostatin regulates tight junction function and composition in human keratinocytes

Vockel

Breitenbach

Kreienkamp

et al. 2010

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Further, previous research demonstrated that the neurohormone somatostatin was strongly expressed in human HF epithelium and had a significant immunosuppressive effect using allogeneic co‐culture cell assays 36 . Somatostatin suppresses T cell activity, 205‐207 inhibits expression of activation markers and proliferation of T cells 208 and decreases IFNγ release by leucocytes 209,210 …”

Section: Mechanisms Of Hf Ipmentioning

confidence: 99%

Hair follicle immune privilege and its collapse in alopecia areata

Bertolini

McElwee

Gilhar

et al. 2020

Experimental Dermatology

182

157

View full text Add to dashboard Cite

Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms protect HFs from physiologically undesired immune responses and limit immune surveillance. IP is relative, not absolute, and is primarily based on absent, or greatly reduced, intra‐follicular antigen presentation via MHC class I and II molecules, along with prominent expression of “no danger” signals like CD200 and the creation of an immunoinhibitory signalling milieu generated by the secretory activities of HFs. Perifollicular mast cells, Tregs and other immunocytes may also contribute to HF IP maintenance in healthy human skin. Collapse of anagen hair bulb IP is an essential prerequisite for the development of alopecia areata (AA). In AA, lesional HFs are rapidly infiltrated by NKG2D + T cells and natural killer (NK) cells, while perifollicular mast cells acquire a profoundly pro‐inflammatory phenotype and interact with autoreactive CD8+ T cells. Using animal models, significant functional evidence has accumulated that demonstrates the dominance of the immune system in AA pathogenesis. Purified CD8+T‐cell and NK cell populations alone, which secrete fγ, suffice to induce the AA phenotype, while CD4+T‐cells aggravate it, and Tregs and iNKT cells may provide relative protection against AA development. While IP collapse may be induced by exogenous agents, inherent IP deficiencies might confer increased susceptibility to AA for some individuals. Thus, a key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse.

show abstract

The Effects of Somatostatin on Immune Cells, Functions and Diseases

Talme

Sundqvist

2012

Nerve-Driven Immunity

View full text Add to dashboard Cite

Psoriasis and Somatostatin in Serum

Cited by 5 publications

References 10 publications

Somatostatin regulates tight junction function and composition in human keratinocytes

Somatostatin regulates tight junction function and composition in human keratinocytes

Hair follicle immune privilege and its collapse in alopecia areata

The Effects of Somatostatin on Immune Cells, Functions and Diseases

Contact Info

Product

Resources

About