Psoriasis causes as much disability as other major medical diseases

Rapp, Stéphen R.; Feldman, Steven R.; Exum, M. Lyn; Fleischer, Alan B.; Reboussin, David M.

doi:10.1016/s0190-9622(99)70112-x

Cited by 1,339 publications

(1,056 citation statements)

References 23 publications

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“…Among PsO patients, 71% of the PsO patients have mild PsO and 27% of PsO patients have moderate–severe PsO, remaining 2% could not be catagorized 20. Reduction in the HRQoL due to PsO is comparable with other chronic diseases such as depression, myocardial infarction, hypertension and even some cancers 21. Reported annual total cost per PsO patient was €8372 in Italy and €2866–6707 in Germany 22.…”

Section: Introductionmentioning

confidence: 99%

Burden of chronic urticaria relative to psoriasis in five European countries

Balp

Khalil

Tian

et al. 2017

Acad Dermatol Venereol

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BackgroundQuantification of burden of chronic spontaneous urticaria (CSU) vs. psoriasis (PsO) is limited.ObjectiveTo evaluate the burden associated with CSU vs. PsO of all severities (overall PsO), mild and moderate/severe PsO.MethodsThis retrospective cross‐sectional analysis compared data from adult patients with chronic urticaria (CU), used as a proxy for CSU, and PsO from the National Health and Wellness Survey in France, Germany, Italy, Spain and the United Kingdom. Outcomes included mental and physical component summary scores (MCS and PCS) calculated from the Short Form (SF)‐36v2 or SF‐12v2, SF‐6D health utility scores, self‐reported psychological complaints (anxiety, depression and sleep difficulties), work productivity and activity impairment, and self‐reported healthcare resource utilization. Bivariate and multivariate analyses for each outcome and comparative groups were conducted.ResultsThis analysis included 769 CU and 7857 PsO (26.9% moderate/severe) patients. Following adjustment for covariates, CU patients showed a greater health‐related quality of life (HRQoL) impairment vs. overall PsO (MCS: −2.4, PCS: −1.6, SF‐6D: −0.03; all P < 0.001). CU patients showed a higher risk of anxiety, depression and sleep difficulties [odds ratio (OR): 1.63, 1.34 and 1.56, respectively; all P < 0.01] and greater healthcare resource use vs. overall PsO. The overall activity impairment was significantly greater in CU patients than in overall PsO patients (P = 0.001), while the impact on work was not significantly different. The results vs. moderate/severe PsO group showed no significant differences on all outcomes.ConclusionBurden of illness in CU is higher than PsO of all severities but similar to that observed in moderate/severe PsO. Both diseases have a similar negative impact on work productivity.

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Section: Introductionmentioning

confidence: 99%

Burden of chronic urticaria relative to psoriasis in five European countries

Balp

Khalil

Tian

et al. 2017

Acad Dermatol Venereol

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“…Bu etkiler her zaman hastal›¤›n klinik fliddeti ile korele olmayabilir ve hafif fliddetteki deri bulgular› bile a¤›r psikososyal bozukluklara yol açabilir 6,7 . Bazen psoriasisin yaflam kalitesi üzerine etkileri, yaflam› tehdit eden kronik sistemik hastal›klar kadar fazla olabilir 8 . Bu nedenle, hastal›k fliddetinin belirlenmesinde dermatolojik bulgularla birlikte psikososyal durumun ve yaflam kalitesinin de¤erlendirilmesi önerilmektedir 9,10 .…”

Section: Giriflunclassified

The Turkish Version of the Psoriasis Disability Index: A Validation and Reliability Study

Fisek¹,

Gökdemir²,

Köşlü³

et al. 2011

TURKDERM

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ÖzetAmaç: Psoriasis vulgaris, hastalar›n yaflam kalitesini önemli ölçüde etkileyen kronik bir hastal›kt›r. Hastal›¤a özgü gelifltirilen ilk ölçek olan "Psoriasis ‹fllev Kayb› ‹ndeksi" (P‹K‹), pek çok dilde geçerlilik ve güvenilirli¤ini kan›tlam›fl ve klinik çal›flmalarda kullan›lm›flt›r. Bu çal›flmada amac›m›z, P‹K‹'ni Türkçeye çevirerek, dilimizde geçerlili¤ini ve güvenilirli¤ini araflt›rmakt›. Gereç ve Yöntem: Ölçek, uluslararas› çeviri basamaklar› izlenerek Türkçeye çevrildi. Hastalar›n Psoriasis alan fliddet indeksi (PAfi‹) skorlar›, demografik ve klinik bulgular› kaydedildi. Güvenilirlik analizi için "iç yap› tutarl›l›¤›" ve "test-tekrar test" metotlar› kullan›ld›. Ölçekteki her bir soru ve alt gruplar için Cronbach alfa katsay›s› ve madde-toplam puan korelasyonlar› hesapland›. Geçerlilik analizi için, "Dermatoloji Yaflam Kalite ölçe¤i"(DYKÖ) ile karfl›laflt›rma yöntemi kullan›ld›. Elde edilen P‹K‹ skorlar›, hastalar›n demografik bulgular› ve klinik özellikleri ile karfl›laflt›r›ld›. Bulgular: Çal›flmaya 161 psoriasis hastas› al›nd›. ‹çyap› tutarl›l›k ölçümünde tüm alt ölçeklerin Cronbach alfa katsay›s› 0,61-0,79 aras›nda de¤iflmekte olup, tüm anket için 0,88 olarak hesapland›. Test-tekrar test güvenilirli¤inde, her bir soru için korelasyon katsay›s› 0,366-0,775 aras›nda de¤iflmekte olup, toplam P‹K‹ skoru için korelasyon katsay›s› r=0,854 olarak hesapland› (p<0,001). Geçerlilik analizleri için, ortalama P‹K‹ ve DYKÖ skorlar› aras›ndaki iliflki araflt›r›ld› ve her iki ölçek aras›nda korelasyon katsay›s› r= 0,674 bulundu (p<0,05). Sonuç: Çal›flmam›z, yap›lan güvenilirlik ve geçerlilik ölçümleri sonucunda P‹K‹'nin Türk psoriasis hastalar› için uygun bir ölçek oldu¤unu göstermektedir. (Türkderm 2011; 45: 24-8) Anahtar Kelimeler: Dermatoloji yaflam kalite ölçe¤i, psoriasis, psoriasis ifllev kayb› indeksi, yaflam kalitesi, türkçe versiyon Summary Background and Design: Several instruments are available for assessing impairment and disability associated with psoriasis. The first psoriasis-specific quality of life questionnaire, Psoriasis Disability Index (PDI), has been translated to many different languages and used in studies all around the world. The aim of this study was to translate the PDI into Turkish and to validate the Turkish version of the PDI and its use for Turkish psoriasis patients, as well as to examine the specific contribution of demographic and clinical features to the PDI. Material and Method: The questionnaire was translated into Turkish by using appropriate translation steps. The socio-demographic data and the Psoriasis Area and Severity Index (PASI) scores of the patients were recorded. For reliability analysis, internal consistency and test-retest method were used. The Cronbach's alpha coefficient and item-total statistics were calculated for each question and subscales. For validation, the questionnaire was compared with the Dermatology Life Quality Index (DLQI). Results: A total of 161 psoriasis patients were included in the study. For internal consistency, Cronbach's alpha coefficient...

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“…The psychological effects of psoriasis can be significant producing anxiety, depression and a negative impact on quality of life comparable to that experienced by patients with cancer, arthritis and heart disease. [12][13][14][15] A sero-negative arthritis (psoriatic arthritis) may occur in 15 per cent of patients and nail disease occurs in 50 per cent.…”

Section: Psoriasismentioning

confidence: 99%