Psoriasis‐like lesions in a patient with familial Mediterranean fever

Ashida, Miwa; Koike, Yuta; Kuwatsuka, Sayaka; Ichinose, Kunihiro; Migita, Kiyoshi; Sano, Shigetoshi

doi:10.1111/1346-8138.13068

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…In this study, there was one HS, one enteropathic arthritis, and three PSA patients. Ashida et al 21 demonstrated Th17 cells in the upper dermis of lesions similar to psoriasis in a patient with FMF. It is estimated that high IL-1 levels in FMF patients may lead to Th17 activation and direct stimulation of keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

“…The level Turk J Int Med 2022;4(1): [25][26][27][28][29][30][31][32][33][34][35][36] Familial Mediterranean Fever and Rheumatic Diseases of IL-1 produced by active T lymphocytes is high in psoriasis lesions. 21 FMF and IBD have many similar clinical and biological properties and may accompany FMF. MEFV mutation has been detected in IBD as well, making diagnosis more challenging.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Tezcan

Gülcemal

Limon

et al. 2022

Turkish Journal of Internal Medicine

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Background Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease affecting mainly the ethnic groups of the Mediterranean basin. It has been reported that it can coexist with various systemic inflammatory diseases. This study aimed to obtain information on rheumatic diseases that accompany FMF and evaluate the relation between FMF and such diseases. Material and MethodsEighty-four patients diagnosed with FMF and have rheumatic disease comorbidity in the rheumatology clinic between January 2018 -March 2020 were included in this study. ResultsThe most common accompanying rheumatic disease was spondyloarthritis (SpA) with 36 patients. Vasculitis was the second common disease accompanying FMF with 22, followed by connective tissue disease (CTD) in 18, juvenile idiopathic arthritis in 4, gout in 3, and hidradenitis suppurativa in 1 patients. The most common MEFV mutation observed was M694V. The rate of patients in the SPA group with signs of fever was significantly higher than those in the vasculitis group. The median C-reactive protein value of the patients in the vasculitis group was significantly higher than the CTD group. There was no statistically significant difference between disease groups regarding to other clinical manifestations and laboratory findings. There was no statistically significant association between disease groups and MEFV mutations regarding to genotype and allelic distribution. Conclusions In this study, the relation between FMF and various rheumatic diseases was determined. Two new conditions, eosinophilic granulomatous polyangiitis and scleroderma were detected. The associations may be just coincidental or an extension of the common underlying pathology. To be aware of this association is important to early diagnosis and appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Tezcan

Gülcemal

Limon

et al. 2022

Turkish Journal of Internal Medicine

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“…Furthermore, there is an excessive response to normal levels of stress occurring at barrier surfaces or at sites of microdamage, which lead to activations of innate immunity components and in later phases of the adaptive immunity and tissue target damage (20). Furthermore, MEFV mutations have been reported by some case reports to be involved also in some SpA-related disorders, mainly those named “MHC-I-opathies” such as BD, AS, and psoriasis (22, 31, 32).…”

Section: Discussionmentioning

confidence: 99%

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

et al. 2019

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Objectives: To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus.Methods: Seven thousand seven hundred forty-seven FMF patients and 10,080 age- and sex-matched controls in the Clalit Health Services medical database were identified and compared in terms of prevalence of SpA-associated disorders. We also evaluated four classical and strong MHC class II-associated disorders, namely, pemphigus vulgaris, myasthenia gravis, sarcoidosis, and pernicious anemia, to ascertain whether such associations with SpA-spectrum disease were specific or merely reflected the non-specific consequences of innate immune system activation on driving divergent types of immunity. The diagnosis of FMF was based on the medical records and not genetically proven.Results: FMF showed a strong association with MHC class I-related diseases: odds ratio (OR) of 28.58 [95% confidence interval (95% CI), 6.93–117.87; p < 0.0001] for Behçet's disease, OR of 10.33 (95% CI, 4.09–26.09; p < 0.0001) for ankylosing spondylitis, and OR of 1.67 (95% CI, 1.19–2.33; p = 0.0029) for psoriasis. For weakly MHC class I-linked diseases, an OR of 3.76 (95% CI, 2.48–5.69; p < 0.0001) for Crohn's disease and OR of 2.64 (95% CI, 1.52–4.56; p = 0.0005) for ulcerative colitis were found. No association was found between FMF and the four MHC class II-associated autoimmune disorders.Conclusion: FMF patients are associated with increased risk of SpA-related disease diagnosis including MHC-I-opathies but not MHC-II-associated autoimmune diseases, suggesting that tissue-specific dysregulation of innate immunity share between FMF and SpA spectrum disorders may drive adaptive immune MHC class I-associated conditions.

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“…Ashida et al. have shown the presence of Th17 cells in the upper dermis of psoriasis-like lesions in a patient with FMF ( 11 ). The level of IL-1 which is produced by active T lymphocytes is high in psoriasis lesions ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…There are case reports for the association of psoriasis with FMF ( 11–13 ), and most recently Barut et al. demonstrated an increased frequency of psoriasis in the relatives of pediatric FMF patients in a cohort study ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Increased psoriasis frequency in patients with familial Mediterranean fever

Erden

Batu

Seyhoglu

et al. 2018

Upsala Journal of Medical Sciences

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ObjectiveFamilial Mediterranean fever (FMF) is a periodic fever syndrome caused by MEFV mutations. FMF may be associated with psoriasis in some cases. The prevalence of psoriasis in the normal Turkish population is 0.42%. We aimed to investigate the prevalence of psoriasis among FMF patients and their relatives.MethodsFMF patients followed at Hacettepe University Adult and Pediatric Rheumatology Departments between January and August 2016 were included. FMF patients/their relatives were accepted to have psoriasis if the diagnosis was made by a dermatologist.ResultsA total of 351 FMF patients (177 adults; 174 children) were included. The median (min–max) age of adult and pediatric patients was 35 (19–63) and 10 (2–18) years, respectively. Thirteen (3.7%) FMF patients (11 adults, 2 children) had psoriasis. Psoriasis was more common in adult than pediatric patients (p = 0.02). Psoriasis was present in 22 (12.4%) of adult and 9 (5.2%) of pediatric patients’ relatives (p = 0.023). The frequency of psoriasis in ≥1 relatives of FMF patients was found to be 8.8%. Abdominal pain and fever were significantly higher, and arthralgia, arthritis, pleural chest pain, and pericarditis were significantly less frequent in the pediatric group than in adults (p < 0.05).ConclusionPsoriasis was more common in FMF patients than in the normal population. Thus, FMF patients should be questioned and carefully examined for psoriasis lesions and psoriasis family history. Prospective multicenter studies may be important to find the incidence of psoriasis in FMF.

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Psoriasis‐like lesions in a patient with familial Mediterranean fever

Cited by 8 publications

References 15 publications

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

Increased psoriasis frequency in patients with familial Mediterranean fever

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