Psoriasis patients show signs of insulin resistance

Abstract

Taken together, several measurements indicative of insulin resistance were found to be significantly correlated with the PASI score. The concept of insulin resistance as a consequence of chronic inflammation and possible pathogenetic cause for comorbidities known to be associated with psoriasis is supported by these data. Our findings validate further studies on larger cohorts as well as interventional studies.

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

“…Insulin resistance, which correlates with PASI, 13 contributes to endothelial dysfunction, manifested by an imbalance in the release of vasodilating and vasoconstricting factors. This imbalance predisposes patients to development of atherosclerosis.…”

Biochemical markers of psoriasis as a metabolic disease

“…Elevated resistin levels have been found in patients with psoriasis, and moreover its concentration corresponded with PASI index [73,83,85]. It is recognized that obesity is associated with chronic inflammation, which is characterized by elevated proinflammatory cytokine synthesis.…”

“…Considering that inflammation mediated by Th1 lymphocytes is one of the factors leading to the development of atherosclerosis and coronary disease [84], it seems that leptin may be a connection between psoriasis and cardiovascular complications [85].…”

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

“…In patients with psoriatic arthritis compared to controls from the Canadian Community Health Survey, the standardized prevalence ratios for MI, angina, and hypertension were increased, whereas the SPRs for CHF and CVA were not 6 of 11 90 …”