Psoriatic arthritis and acquired immunodeficiency syndrome

Espinoza, Luis R.; Berman, Alberto; Vasey, Frank B.; Cahalin, Cay; Nelson, Robert S.; Germain, Bernard F.

doi:10.1002/art.1780310815

Cited by 66 publications

(12 citation statements)

References 29 publications

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“…ficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I) also induce conditions that can resemble classic autoimmune diseases, and the diseases induced by these agents may have important autoimmune components Espinoza et al, 1988;Garry et al, 1995). Furthermore, HIVinfected persons often produce a variety of autoantibodies (Muller et al, 1992;Stricker et al, 1985Stricker et al, , 1987.…”

Section: Introductionmentioning

confidence: 99%

Involvement of human intracisternal A‐type retroviral particles in autoimmunity

Sander

Szabo

Gallaher

et al. 2005

Microscopy Res & Technique

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Prior studies have linked retroviruses to various arthropathies and autoimmune diseases. Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by aggressive infiltration of lymphocytes into the salivary and lacrimal glands, resulting in destruction of the glands and dry mouth and eyes (sicca syndrome). The infiltrating lymphocytes in SS may become overtly malignant, and thus, the incidence of lymphoma is greatly increased in SS patients. A human intracisternal A-type retroviral particle type I (HIAP-I) has been isolated from persons with SS. HIAP-I shares a limited number of antigenic epitopes with human immunodeficiency virus (HIV), but is distinguishable from HIV by morphological, physical, and biochemical criteria. A substantial majority of patients with SS or systemic lupus erythematosus (SLE) have serum antibodies to the proteins of this human retrovirus. Fewer than 3% of the normal blood donor population have antibodies to any HIAP-associated proteins. A second type of a human intracisternal A-type retrovirus, HIAP-II, was detected in a subset of patients with idiopathic CD4 lymphocytopenia (ICL), an AIDS-like immunodeficiency disease. Most HIAP-II positive ICL patients were also antinuclear antibody positive. Reviewed here are additional studies from several laboratories suggesting that HIAP or related viruses may be involved in SLE and other autoimmune conditions. Additionally, results of comprehensive surveys of autoimmune patients to determine seroreactivity to HIAP, and other human retroviruses, including HIV and human T-lymphotropic virus type I, are reported.

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Section: Introductionmentioning

confidence: 99%

Involvement of human intracisternal A‐type retroviral particles in autoimmunity

Sander

Szabo

Gallaher

et al. 2005

Microscopy Res & Technique

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“…The most common form of articular involvement is polyarticular and asymmetric. Sacroiliac and spine involvement may also occur (12). Nail involvement occurs in most patients who present with inflammatory articular symptoms.…”

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confidence: 99%

Rheumatic manifestations associated with human immunodeficiency virus infection

Espinoza

Aguilar

Berman

et al. 1989

Arthritis & Rheumatism

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“…Therefore, it is difficult to prove a pathogenic role for such antigens, as secondary infection of psoriatic plaques is common. Some reports have suggested that HIV and hepatitis C virus may play a more significant role in the pathogenesis of psoriasis arthritis [7,8]. Both of acute guttate psoriasis and psoriatic arthritis are the common phenotypes of psoriasis.…”

Section: Discussionmentioning

confidence: 99%