Psoriatic arthritis – new perspectives

Abstract

Psoriatic arthritis (PsA) is a seronegative arthropathy with many clinical manifestations, and it may affect nearly a half of patients with psoriasis. PsA should be diagnosed as early as possible to slow down joint damage and progression of disability. To improve the diagnosis of PsA, physicians should look for peripheral inflammatory pain, axial inflammatory pain, dactylitis, and buttock and sciatic pain. In most patients with PsA, pharmacologic treatment with non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biologic agents is effective. However, when pharmacological treatment fails, patients with PsA may benefit from orthopedic surgery, which can improve both joint function and quality of life. Total hip arthroplasty, total knee arthroplasty, and arthroscopic synovectomy of the knee are the most common surgical procedures offered to patients with PsA. The management of PsA requires the care of a multidisciplinary team, which should include dermatologists, rheumatologists, physiotherapists, and orthopedic surgeons.

The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength

“…In the present day, the advance of science remains fast-paced, especially in disciplines associated with medicine and human life. The need to save human lives, relieve pain, reconstruct parts of the human body after injuries, and, finally, cure those suffering from various kinds of local or systemic ailments using traditional methods [ 1 ] are the flywheels of progress both in medicine itself and many other disciplines that are subsidiary to medicine in terms of their classification, but which share its goals, such as material engineering and, in particular, the development of biomaterials [ 2 , 3 , 4 ]. Some biomaterials used to aid patients are bone cements.…”

Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio

“…Every year, several million patients require surgical treatment on account of bone defects or to reconstruct joint surfaces resulting from diseases or mechanical injuries. Thus, there is a distinct rise in the number of arthroplasty procedures performed on an annual basis [1,2,3,4]. There are several causes behind the observed tendency, including rising qualifications of surgeons to perform these procedures or the increase in life expectancy.…”

The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report

“…TNF-α is a pleiotropic cytokine that stimulates, among others, T-cell proliferation, B-cell proliferation and differentiation and their release of proinflammatory cytokines. Under the influence of P r e p r i n t activated T lymphocytes, there is an increased proliferation of keratinocytes and thus resistance to apoptosis [4][5][6][7][8][9]. Psoriasis patients are often diagnosed with so-called comorbid diseases, which are included in the circle of metabolic syndrome.…”