PSV-B-28 Late-Breaking: Development and validation of a Total Inflammation Index™ for identifying inflammation in Labrador Retrievers using a pressure walkway

Varney, Jessica L; Coon, C. N.

doi:10.1093/jas/skab235.702

Cited by 1 publication

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“…Improvements in both pain assessments and gait analysis for undenatured type II collagen supplemented dogs agreed with the previously reported results of improved activity during runs and improved biomarker activity ( Varney et al, 2021 ). Reductions in cartilage oligomeric matrix protein (COMP) and pro-inflammatory cytokine interleukin-6 (IL-6) appear to be associated with improvement in the pain assessments and gait analysis.…”

Section: Discussionsupporting

confidence: 90%

“…The results of this study indicated that supplementation with undenatured type II collagen limits the development of pain and impaired mobility after exercise in Labrador Retrievers based on subjective pain assessments and objective gait analysis. Previously, we reported that supplementation of undenatured type II collagen limits the increase of pro-inflammatory and cartilage degeneration biomarkers in the serum of Labrador Retrievers after exercise ( Varney et al, 2021 ). During the same experiment, all dogs were scored using the pain assessments and gait analysis with results presented herein.…”

Section: Discussionmentioning

confidence: 99%

“…However, caregiver bias can also be present when subjectively assessing mobility in dogs at rates of up to approximately 40% for owners and up to 45% for veterinarians ( Conzemius and Evans, 2012 ). For an objective measure of the effectiveness of undenatured type II collagen on mobility, gait analysis and calculation of the FRK Inflammation Index were used ( Assaf et al, 2019 ) ( Nielsen et al, 2020 ) ( Varney and Coon, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…All dogs wore Actical accelerometer collars (Starr Life Sciences Corp; Oa kmont, PA) to quantify activity intensity and GPS collars (Garmin Intl; Olathe, KS) to determine actual distance ran and average moving speed. Data are presented in a previous publication ( Varney et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Supplements, nutraceuticals, and prescription medications all have their roles in the reduction of symptoms of arthritis and joint pain. Undenatured type II collagen is a glycoprotein derived from chicken sternum cartilage that has recently been shown t o prevent the increase of pro-inflammatory and cartilage degeneration biomarkers in Labrador Retrievers after exercise ( Varney et al, 2021 ). Undenatured type II collagen (UC-II supplementation) works by stabilizing cartilage through an increased composition of amino acids glycine and proline ( Walrand et al, 2008 ), as well as preventing immune reactivity and destruction of cartilage via glycosylation ( Bagchi et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

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Impact of supplemented undenatured type II collagen on pain and mobility in healthy Labrador Retrievers during an exercise regimen

Varney

Fowler

Coon

2022

Translational Animal Science

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The aim of this experiment was to evaluate the effect of undenatured type II collagen supplementation on inflammation and pain using gait analysis and industry-accepted pain and mobility questionnaires during an exercise regimen in healthy dogs. Forty healthy Labrador Retrievers (20 male/20 female; Range: 5-12yrs) were sorted into two groups: undenatured type II collagen group receiving 40mg UC-II product (10mg total collagen and ≥3% undenatured type II collagen) and placebo group receiving 40mg maltodextrin daily by capsule. After 2wks loading, all dogs began an 11wk endurance exercise regimen consisting of two weekly runs, starting at 5km and increasingly incrementally to 8km, with one final 16km run. Gait analysis was performed at baseline; before, 24h and 48h after the first 5km run; and before, 24h and 48h after the final 16km run. Gait analysis was calculated to obtain a Four Rivers Kennel (FRK) Inflammation Index score. Dogs were scored according to the Liverpool Osteoarthritis in Dogs (LOAD) and Canine Brief Pain Inventory (CBPI) assessments at baseline, before and after the first 5km run, and before and after the final 16km run. On the LOAD questionnaire, undenatured type II collagen group had improved “how active is the dog” (P=0.03) and less “stiffness after a lie down” (P=0.041) compared with placebo at pre 5km. Undenatured type II collagen appeared to mitigate the development of pain after exercise compared with placebo, as related to the CPBI assessment. Undenatured type II collagen dogs had lower “pain at worst” pre 5km (P=0.021), “pain at least” post 5km (P=0.015), “pain at average” post 5km (P=0.046), and “pain as it is now” post 16km (P=0.006) compared with placebo dogs. Undenatured type II collagen was more effective than placebo at mitigating inflammation on gait analysis per the FRK Inflammation Index. Undenatured type II collagen dogs had a 6.42 lower FRK Inflammation Index score at 24h post 5km (P=0.032) and 6.3 lower score at 24h post 16km (P=0.029), indicating the mitigation of inflammation on gait analysis. When considering the change between timepoints, undenatured type II collagen had a lower increase in FRK Inflammation scores compared with placebo for baseline to pre 5km (p<0.001), pre 16km to 24h post 16km (P=0.028), and pre 16km to 48h post 16km (P=0.027). Undenatured type II collagen supplemented Labrador Retrievers improved pain assessment variables and improved FRK Inflammation Index on gait analysis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%