Psychiatric diagnoses in patients who screen positive on the Mood Disorder Questionnaire: Implications for using the scale as a case-finding instrument for bipolar disorder

Zimmerman, Mark; Galione, Janine N.; Chelminski, Iwona; Young, Diane; Dalrymple, Kristy

doi:10.1016/j.psychres.2010.06.025

Cited by 48 publications

(43 citation statements)

References 33 publications

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“…In each of these studies, however, the differences found between patients who screened positive and negative on MDQ may have been due not to bipolar disorder; but to other forms of psychopathology. Zimmerman and colleagues 50,51 found that in psychiatric outpatients, false-positive MDQ results are associated with elevated rates of borderline personality disorder, anxiety, impulse control, substance use, and attention-deficit disorders. Similar studies of false-positive diagnoses in general population community samples have not been conducted.…”

Section: Discussionmentioning

confidence: 99%

Screening for Bipolar Disorder with the Mood Disorders Questionnaire: A Review

Zimmerman

Galione

2011

Harvard Review of Psychiatry

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The MDQ's performance depends upon the setting in which it is used, the threshold to identify caseness, and the subtype of bipolar disorder examined. Conceptual issues in the use of a bipolar disorder screening questionnaire are discussed, and questions are raised about the clinical value of a self-report screening scale for bipolar disorder. Based on current available evidence, routine clinical use of the MDQ cannot be recommended because of the absence of studies simultaneously examining both the potential benefits (e.g., improved detection) and costs (e.g., overdiagnosis) of screening.

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Section: Discussionmentioning

confidence: 99%

Screening for Bipolar Disorder with the Mood Disorders Questionnaire: A Review

Zimmerman

Galione

2011

Harvard Review of Psychiatry

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“…It is one of the most frequently studied bipolar disorder screening inventories world widely 13–19). However, many studies have criticized MDQ’s usefulness and its discriminatory power for bipolar disorder 7,20–24). Additionally, some studies have suggested adjusting the cutoff value to enhance the instrument’s sensitivity 25,26)…”

Section: Introductionmentioning

confidence: 99%

Improving the Screening Instrument of Bipolar Spectrum Disorders: Weighted Korean Version of the Mood Disorder Questionnaire

Hong

Bahk

Yoon

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveIt is not easy to diagnose bipolar disorders accurately in the clinical setting. Although Korean version of the Mood Disorder Questionnaire (K-MDQ) is easily administered, it still has weakness regarding case finding. In this study, we suggest a new weighted version of the K-MDQ to increase its screening power.MethodsNinety-five patients with bipolar disorders and 346 controls (patients with schizophrenia, patients with depressive disorders, patients with anxiety disorders, and subjects without any psychiatric disease) were enrolled in this study. The subjects received brief information on the K-MDQ, and then independently completed the questionnaire.ResultsUsing odds ratios, we constructed a new weighted K-MDQ (W-K-MDQ). Item 1 (feel so good or hyper) was weighted 7 times and item 4 (less sleep) 3.5 times. Item 7 (easily distracted) and item 11 (more interested in sex) were excluded. Part 2 (simultaneity) and 3 (functional impairment) were also excluded as in the original K-MDQ. The sensitivity of the W-K-MDQ with a cutoff value of 10 was enhanced to 0.789. The area under the receiver operating characteristic curve was increased to 0.837.ConclusionWe suggested a new formula for K-MDQ using 11 of its items. The W-K-MDQ can be easily applied with good sensitivity to screen for bipolar disorders in clinical settings in Korea. Further evaluations with larger samples are needed to establish the usefulness of the W-K-MDQ.

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“…34 Subsequent research on the MDQ, however, has suggested that patients with positive MDQ screens were as likely to have borderline personality disorder as bipolar disorder. 35 In another study, most patients who screened positive on the MDQ 36 were found to have posttraumatic stress disorder, eating disorders and substance use disorders (based on a standardized clinical interview, SCID-IV), rather than bipolar disorder. The MDQ is a screening tool rather than a case-finding tool;, the high false positive rate requires that patients who screen positive should undergo further diagnostic assessment 37 (see example followup questions in Tables 3 and 4).…”

Section: Screening and Case Identification Toolsmentioning

confidence: 99%