Psychiatric Disorder, Irritable Bowel Syndrome and Extra-Intestinal Symptoms in a Population-Based Sample of Twins

Lembo, Anthony; Zaman, Maseeh uz; Krueger, Robert F.; Tomenson, Barbara; Creed, Francis

doi:10.1038/ajg.2009.23

Cited by 22 publications

(22 citation statements)

References 64 publications

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“…A study published just recently reported concordance rates for increased somatic symptom scores of 30% for monozygotic twins (MZ) compared to 17% in dizygotic twins (DZ). Noteworthy, even after adjustment for psychiatric disorders and irritable bowel syndrome, the odds ratios remained higher in MZ compared to DZ [22]. For other disorders characterized by multiple somatic symptoms such as fibromyalgia, familiar aggregation has also been found [23].…”

Section: Genetic Aspects In Somatic Symptoms and Depressionmentioning

confidence: 81%

Psychobiological differences between depression and somatization

Rief

Hennings

Riemer

et al. 2010

Journal of Psychosomatic Research

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Section: Genetic Aspects In Somatic Symptoms and Depressionmentioning

confidence: 81%

Psychobiological differences between depression and somatization

Rief

Hennings

Riemer

et al. 2010

Journal of Psychosomatic Research

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“…1984, 1987; Lackner et al 2006) and pharmacological (Creed et al 2003), have demonstrated efficacy in the treatment of GI symptoms in IBS. Studies commonly report an increased prevalence of depression and anxiety, and affected patients often have a formal, psychiatrically diagnosed mood disorder (Hazlett-Stevens et al 2003; Creed et al 2005, 2008; Lembo et al 2009; Mykletun et al 2010). In addition, mounting evidence from functional magnetic resonance imaging (fMRI) research indicates that, in response to visceral pain stimulation, patients with IBS exhibit abnormal brain activity in regions involved in pain processing and endogenous pain modulation (Mayer et al 2009; Tillisch et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory

et al. 2013

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BackgroundCentral nervous system (CNS) dysfunction is a prominent feature of the functional gastrointestinal (GI) disorder, irritable bowel syndrome (IBS). However, the neurobiological and cognitive consequences of key pathophysiological features of IBS, such as stress-induced changes in hypothalamic–pituitary–adrenal (HPA)-axis functioning, is unknown. Our aim was to determine whether IBS is associated with cognitive impairment, independently of psychiatric co-morbidity, and whether cognitive performance is related to HPA-axis function.MethodA cross-sectional sample of 39 patients with IBS, a disease control group of 18 patients with Crohn's disease (CD) in clinical remission and 40 healthy age- and IQ-matched control participants were assessed using the Paired Associates Learning (PAL), Intra-Extra Dimensional Set Shift (IED) and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and a computerized Stroop test. HPA-axis function was determined by measuring the cortisol awakening response (CAR).ResultsIBS patients exhibited a subtle visuospatial memory deficit at the PAL six- pattern stage (p = 0.03), which remained after psychiatric co-morbidity was controlled for (p = 0.04). Morning cortisol levels were lower in IBS (p = 0.04) and significantly associated with visuospatial memory performance within IBS only (p = 0.02).ConclusionsFor the first time, altered cognitive function on a hippocampal-mediated test of visuospatial memory, which was related to cortisol levels and independent of psychiatric co-morbidity, has been identified in IBS. Visuospatial memory impairment may be a common, but currently neglected, component of IBS. Further elucidation of the nature of this impairment may lead to a greater understanding of the underlying pathophysiology of IBS, and may provide novel therapeutic approaches.

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“…There is evidence for a genetic tendency to develop bodily distress distinct from that for anxiety and depression [49,50]. …”

Section: Etiologymentioning

confidence: 99%

Management of Functional Somatic Syndromes and Bodily Distress

Henningsen

Zipfel²,

Sattel³

et al. 2018

Psychother Psychosom

242

182

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Functional somatic syndromes (FSS), like irritable bowel syndrome or fibromyalgia and other symptoms reflecting bodily distress, are common in practically all areas of medicine worldwide. Diagnostic and therapeutic approaches to these symptoms and syndromes vary substantially across and within medical specialties from biomedicine to psychiatry. Patients may become frustrated with the lack of effective treatment, doctors may experience these disorders as difficult to treat, and this type of health problem forms an important component of the global burden of disease. This review intends to develop a unifying perspective on the understanding and management of FSS and bodily distress. Firstly, we present the clinical problem and review current concepts for classification. Secondly, we propose an integrated etiological model which encompasses a wide range of biopsychosocial vulnerability and triggering factors and considers consecutive aggravating and maintaining factors. Thirdly, we systematically scrutinize the current evidence base in terms of an umbrella review of systematic reviews from 2007 to 2017 and give recommendations for treatment for all levels of care, concentrating on developments over the last 10 years. We conclude that activating, patient-involving, and centrally acting therapies appear to be more effective than passive ones that primarily act on peripheral physiology, and we recommend stepped care approaches that translate a truly biopsychosocial approach into actual management of the patient.

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Psychiatric Disorder, Irritable Bowel Syndrome and Extra-Intestinal Symptoms in a Population-Based Sample of Twins

Abstract: Extra-intestinal symptoms are independently associated with both IBS and psychiatric disorders. There is evidence that there is a genetic basis to EIS, but the association with IBS and psychiatric disorders is not primarily explained by genetic influences.

Cited by 22 publications

References 64 publications

Psychobiological differences between depression and somatization

Psychobiological differences between depression and somatization

Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory

Management of Functional Somatic Syndromes and Bodily Distress

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