Psychiatric genetic counseling for serious mental illness: Impact on psychopathology and psychotropic medication adherence

Morris, Emily; Batallones, Rolan; Ryan, Jane; Slomp, Caitlin; Carrion, Prescilla; Albert, Arianne; Austin, Jehannine

doi:10.1016/j.psychres.2020.113663

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…Rather than arguing that genetic information is dangerous or should not be distributed, our results can be used to highlight sensitive areas that should be explicitly addressed in educational campaigns or when disclosing personal genetic information. In fact, the few studies that have been conducted on the impact of psychiatric genetic counseling suggest that genetic counseling can increase empowerment and self-efficacy in individuals with mental illness (Inglis, Koehn, McGillivray, Stewart, & Austin, 2015) and reduce some of their symptoms, above and beyond medication adherence (Morris et al, 2021). Altogether, these results support the idea that psychiatric 2019) who did look into this question, found that belief in genetic determinism, gender, and parenthood, were significantly associated with accuracy in lay estimates of heritability.…”

Section: Discussionmentioning

confidence: 71%

Investigating perceived heritability of mental health disorders and attitudes toward genetic testing in the United States, United Kingdom, and Australia

Morosoli

Colodro‐Conde

Barlow

et al. 2021

American J of Med Genetics Pt B

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Our beliefs about the heritability of psychiatric traits may influence how we respond to the use of genetic information in this area. In the present study, we aim to inform future education campaigns as well as genetic counseling interventions by exploring common fears and misunderstandings associated with learning about genetic predispositions for mental health disorders. We surveyed 3,646 genetic research participants from Australia, and 960 members of the public from the United Kingdom, and the United States, and evaluated attitudes toward psychiatric genetic testing. Participants were asked hypothetical questions about their interest in psychiatric genetic testing, perceived usefulness of psychiatric genetic testing, and beliefs about malleability of behavior, among others. We also asked them to estimate the heritability of alcohol dependence, schizophrenia, and major depression. We found a high interest in psychiatric genetic testing. In most cases, more than a third of the participants showed serious concerns related to learning about personal genetic predisposition, such as not wanting to have children if they knew they had a high genetic predisposition, or not wanting to choose a partner with a high genetic predisposition for a mental health problem. Finally, we found a significant association between most participants' attitudes and their lay estimates of heritability, which highlights the complexity of educating the public about genetics.

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Section: Discussionmentioning

confidence: 71%

Investigating perceived heritability of mental health disorders and attitudes toward genetic testing in the United States, United Kingdom, and Australia

Morosoli

Colodro‐Conde

Barlow

et al. 2021

American J of Med Genetics Pt B

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“…Although psychiatric conditions are common [7 ▪▪ ], historically, their underlying causes have not always been well understood and research examining the underlying biology of psychiatric conditions is ongoing [8]. Yet, academics have long recognized the multifactorial nature of psychiatric conditions.…”

Section: The Current State Of Psychiatric Geneticsmentioning

confidence: 99%

“…Today, there is considerable evidence that multiple genetic and environmental factors contribute to the development of psychiatric conditions [7 ▪▪ ,8,10 ▪▪ ,11 ▪▪ ]. All major psychiatric conditions have a heritable component [8], with the heritability of many being quite high; estimates for schizophrenia, autism spectrum disorder (ASD) and bipolar disorder are some of the highest (0.81, 0.80 and 0.75, respectively) [5].…”

Section: The Current State Of Psychiatric Geneticsmentioning

confidence: 99%

Genetic testing for psychiatric illness in children: ethical issues

Lynch

Vears

2022

Current Opinion in Pediatrics

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Purpose of reviewGenetic and genomic technologies are showing great potential in the field of psychiatry. Genetic testing for psychiatric conditions poses a range of ethical challenges, many of which are likely to be exacerbated for paediatric populations. As a large proportion of psychiatric conditions present in late adolescence and early adulthood, testing in childhood may be considered in some circumstances. Synthesis of issues specific to psychiatric genetic testing in paediatric populations has been limited.Recent findingsBalancing the autonomy of the child and parents requires consideration and judging capacity may be complicated by the presence of psychiatric illness in the child and their family. Health professionals’ limited understanding of psychiatric genetics may inhibit delivery of effective psychiatric care. Risk of stigma and discrimination associated with genetic diagnosis and psychiatric illness is compounded for children, who inherently cannot make their own decisions and for whom the impact of a genetic diagnosis is likely to be longest lasting.SummaryAlthough the current evidence base suggests genetic testing may not be appropriate for clinical use in psychiatric populations right now, when it is, appropriate pre-test counselling and informed decision making will be essential to support and protect children's developing and future autonomy.

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“…We aimed to learn whether these behavioral changes have any impact on mental health outcomes. Only one study has explored this to date—and generated evidence that suggests improvements to psychiatric symptoms after pGC 27 . Another way of exploring the potential effects of pGC on mental health outcomes is to use convenience data (that already exist), such as population health data about psychiatric hospitalizations (see Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of psychiatric genetic counseling on psychiatric hospitalizations

Morris,

McGrail,

Cressman

et al. 2024

Clinical Genetics

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Psychiatric genetic counseling (pGC) can improve patient empowerment and self‐efficacy. We explored the relationship between pGC and psychiatric hospitalizations, for which no prior data exist. Using Population Data BC (a provincial dataset), we tested two hypotheses: (1) among patients (>18 years) with psychiatric conditions who received pGC between May 2010 and Dec 2016 (N = 387), compared with the year pre‐pGC, in the year post‐pGC there would be fewer (a) individuals hospitalized and (b) total hospital admissions; and (2) using a matched cohort design, compared with controls (N = 363, matched 1:4 for sex, diagnosis, time since diagnosis, region, and age, and assigned a pseudo pGC index date), the pGC cohort (N = 91) would have (a) more individuals whose number of hospitalizations decreased and (b) fewer hospitalizations post‐pGC/pseudo‐index. We also explored total days in hospital. Within the pGC cohort, there were fewer hospitalizations post‐pGC than pre‐ pGC (p = 0.011, OR = 1.69), and total days in hospital decreased (1085 to 669). However, when compared to matched controls, the post‐pGC/pseudo index change in hospitalizations among pGC cases was not statistically significant, even after controlling for the higher number of hospitalizations prior. pGC may lead to fewer psychiatric hospitalizations and cost savings; further studies exploring this are warranted.

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Psychiatric genetic counseling for serious mental illness: Impact on psychopathology and psychotropic medication adherence

Cited by 7 publications

References 33 publications

Investigating perceived heritability of mental health disorders and attitudes toward genetic testing in the United States, United Kingdom, and Australia

Investigating perceived heritability of mental health disorders and attitudes toward genetic testing in the United States, United Kingdom, and Australia

Genetic testing for psychiatric illness in children: ethical issues

Assessing the impact of psychiatric genetic counseling on psychiatric hospitalizations

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