Psychiatric Implications of Adolescent Methamphetamine Exposures

Auten, Jonathan D.; Matteucci, Michael J.; Gaspary, Micah J; Combs, Daniel J.; Clark, Richard F.

doi:10.1097/pec.0b013e31823ed6ca

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…The experience of psychotic symptoms (delusions and auditory hallucinations) has been reported in over half of a sample of cannabis and cocaine substance abusers, either during the use or withdrawal of those substances (Smith et al, 2009). Dependent users of cocaine (Mahoney et al, 2008), opiates (Smith et al, 2009), methamphetamine (Srisurapanont et al, 2003; Auten et al, 2012) and cannabis (Arendt et al, 2005) also experience delusions and AVH (Smith et al, 2009), usually in over 50% of responses for each study. The severity of the psychotic symptoms are almost always significantly related to the rate of substance use, such that severity of psychotic symptomatology increased with increasing rate of dependence.…”

Section: Substance-induced Auditory Verbal Hallucinationsmentioning

confidence: 99%

A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals

Leede-Smith¹,

Barkus²

2013

Front. Hum. Neurosci.

166

131

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Over the years, the prevalence of auditory verbal hallucinations (AVHs) have been documented across the lifespan in varied contexts, and with a range of potential long-term outcomes. Initially the emphasis focused on whether AVHs conferred risk for psychosis. However, recent research has identified significant differences in the presentation and outcomes of AVH in patients compared to those in non-clinical populations. For this reason, it has been suggested that auditory hallucinations are an entity by themselves and not necessarily indicative of transition along the psychosis continuum. This review will examine the presentation of auditory hallucinations across the life span, as well as in various clinical groups. The stages described include childhood, adolescence, adult non-clinical populations, hypnagogic/hypnopompic experiences, high schizotypal traits, schizophrenia, substance induced AVH, AVH in epilepsy, and AVH in the elderly. In children, need for care depends upon whether the child associates the voice with negative beliefs, appraisals and other symptoms of psychosis. This theme appears to carry right through to healthy voice hearers in adulthood, in which a negative impact of the voice usually only exists if the individual has negative experiences as a result of their voice(s). This includes features of the voices such as the negative content, frequency, and emotional valence as well as anxiety and depression, independently or caused by voices presence. It seems possible that the mechanisms which maintain AVH in non-clinical populations are different from those which are behind AVH presentations in psychotic illness. For example, the existence of maladaptive coping strategies in patient populations is one significant difference between clinical and non-clinical groups which is associated with a need for care. Whether or not these mechanisms start out the same and have differential trajectories is not yet evidenced. Future research needs to focus on the comparison of underlying factors and mechanisms that lead to the onset of AVH in both patient and non-clinical populations.

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Section: Substance-induced Auditory Verbal Hallucinationsmentioning

confidence: 99%

A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals

Leede-Smith¹,

Barkus²

2013

Front. Hum. Neurosci.

166

131

View full text Add to dashboard Cite

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“…Recent studies have claimed that adolescents who took MA led to side effects in the neural system. 2,3 Researchers have confirmed that MA induces oxidative stress, inflammation, and apoptosis in the cerebral regions such as hippocampus, 4 –6 but the underlying molecular mechanisms and signaling pathways involved in MA abuse remained unclear.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron

Yang

et al. 2020

Hum Exp Toxicol

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Objective: Methamphetamine (MA) abuse induces neurotoxicity and causes neuronal cell apoptosis. Gastrodin is a traditional Chinese herbal medicine used for the treatment of nerve injuries, spinal cord injuries, and some central nervous system diseases as well. The present study investigated the neuroprotective effects of gastrodin against MA-induced neurotoxicity in neuronal cells and its potential protective mechanism. Methods: The primary cortex neuronal culture was divided into four groups (control group, MA group, MA + gastrodin group, and MA + gastrodin + small interfering RNA group). The neurotoxicity of MA was assessed by detecting apoptotic cells by terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay and cell viability by cell counting kit 8 (CCK-8) method, the Tuj1-positive cells and the average axonal length were detected by immunofluorescence, and the expressions of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response element-binding (CREB), and brain-derived neurotrophic factor (BDNF) proteins were detected by Western blot. Results: The results of CCK-8 assay showed that 0.5 mM MA was an optimal concentration that induced neurotoxicity ( p < 0.01). Pretreatment with 25 mg/L gastrodin exerted maximum protective effects on neuronal cells. The expression levels of cAMP, PKA, phosphorylated PKA, CREB, phosphorylated CREB, and BDNF proteins were decreased in the MA group, and pretreatment with gastrodin upregulated the expression levels of these proteins ( p < 0.01). The expressions of PKA and CREB proteins showed no significant changes in the control group, MA group, and gastrodin group. Compared the MA + gastrodin + small interfering RNA group with MA + gastrodin group, the Tuj1-positive cells and the average axonal length were decreased significantly, while the number of apoptotic cells was increased ( p < 0.05). Conclusion: Gastrodin has neuroprotective effects against MA-induced neurotoxicity, which exerts neuroprotective effects via regulation of cAMP/PKA/CREB signaling pathway and upregulates the expression of BDNF.

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“…Bupropion was well tolerated except for one episode of suicidal ideation, a known complication of antidepressants in adolescents, which also may have been triggered by the participant’s methamphetamine relapse [8]. Methamphetamine dependence and cravings, marijuana use, conduct disorder, ADHD, and depressive symptoms were more frequent in the bupropion than placebo group which may explain the poor outcomes observed in the bupropion group.…”

Section: Discussionmentioning

confidence: 99%

Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

Heinzerling

Gadzhyan

Oudheusden

et al. 2013

Journal of Adolescent Health

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Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents Methods 19 adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = 0.043) and males (p = 0.005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.

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Psychiatric Implications of Adolescent Methamphetamine Exposures

Abstract: In this data set, adolescent methamphetamine exposures were associated with increased rates of suicidal ideation and suicide attempts that are disproportionate to population-based surveys during the same period.

Cited by 9 publications

References 12 publications

A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals

A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals

Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron

Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

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