Psychiatric medications: Adverse cutaneous drug reactions

Bliss, Sarah; Warnock, Julia K.

doi:10.1016/j.clindermatol.2011.11.014

Cited by 43 publications

(26 citation statements)

References 84 publications

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“…Most commonly, SSRIs have been associated with petechiae and ecchymosis, which occur secondarily to the effects SSRIs on platelet aggregation [48]. Some individuals can develop skin reactions on the face, neck and dorsum of the hands secondary to excessive exposure to sunlight [47,48].…”

Section: Hepatotoxicity and Hypersensitivity Reactionsmentioning

confidence: 99%

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Carvalho

Sharma²,

Brunoni³

et al. 2016

Psychother Psychosom

508

324

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Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later. They encompass gastrointestinal symptoms (nausea, diarrhea, gastric bleeding, dyspepsia), hepatotoxicity, weight gain and metabolic abnormalities, cardiovascular disturbances (heart rate, QT interval prolongation, hypertension, orthostatic hypotension), genitourinary symptoms (urinary retention, incontinence), sexual dysfunction, hyponatremia, osteoporosis and risk of fractures, bleeding, central nervous system disturbances (lowering of seizure threshold, extrapyramidal side effects, cognitive disturbances), sweating, sleep disturbances, affective disturbances (apathy, switches, paradoxical effects), ophthalmic manifestations (glaucoma, cataract) and hyperprolactinemia. At times, such adverse events may persist after drug discontinuation, yielding iatrogenic comorbidity. Other areas of concern involve suicidality, safety in overdose, discontinuation syndromes, risks during pregnancy and breast feeding, as well as risk of malignancies. Thus, the rational selection of ADs should consider the potential benefits and risks, likelihood of responsiveness to the treatment option and vulnerability to adverse events. The findings of this review should alert the physician to carefully review the appropriateness of AD prescription on an individual basis and to consider alternative treatments if available.

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Section: Hepatotoxicity and Hypersensitivity Reactionsmentioning

confidence: 99%

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Carvalho

Sharma²,

Brunoni³

et al. 2016

Psychother Psychosom

508

324

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“…7Lurasidone has a limited side-effect profile, with no adverse cutaneous events having been reported before it was marketed. 1 Conversely, olanzapine has been associated with cutaneous adverse drug reactions, including a similar incidence of hyperpigmentation reported by Jhirwal et al 1,3 We believe that drug-induced hyperpigmentation is a rare side-effect of olanzapine, but physicians should be aware of it.Although it is possible that the patient's hyperpigmentation resulted from pigment deposition caused by olanzapine, we cannot rule out the possibility of a photoirritant or photoallergic reaction. We were unable to photopatch test the patient, but remain interested in the possibility of systemic photoallergy presenting with hyperpigmentation.…”

mentioning

confidence: 63%

“…Lurasidone has a limited side‐effect profile, with no adverse cutaneous events having been reported before it was marketed . Conversely, olanzapine has been associated with cutaneous adverse drug reactions, including a similar incidence of hyperpigmentation reported by Jhirwal et al We believe that drug‐induced hyperpigmentation is a rare side‐effect of olanzapine, but physicians should be aware of it.…”

Section: Discussionmentioning

confidence: 99%

Dorsal hand skin hyperpigmentation following oral olanzapine (Zyprexa) use

Cary

Maibach

2018

Contact Dermatitis

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“…Language was restricted to English, German, Dutch and Scandinavian language. Some review articles refer to cases concerning exacerbation of psoriasis during treatment with risperidone and quetiapine [24]. However, these cases were not published in journals indexed for medline or pubmed.…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic-associated psoriatic rash – a case report

et al. 2017

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BackgroundAntipsychotics are a heterogeneous group of drugs. Although, antipsychotics have been used for years, unexpected side effects may still occur. With this case report we focus on a possible association between psoriasis and antipsychotics.Data on the patient’s course of psychiatric disease, onset of psoriasis and its evolution were extracted from the patient’s medical files.Case presentationWe present a case of a 21-year-old female diagnosed with schizophrenia. She was initially treated with quetiapine, and later switched to aripiprazole due to weight gain. After initiation of antipsychotic treatment, the patient suffered from severe psoriasis lesions.ConclusionsAntipsychotics may possess immunological properties that may be involved in immune-mediated conditions, such as psoriatic rash. Further studies are warranted to determine causality and mechanism.

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Psychiatric medications: Adverse cutaneous drug reactions

Cited by 43 publications

References 84 publications

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Dorsal hand skin hyperpigmentation following oral olanzapine (Zyprexa) use

Antipsychotic-associated psoriatic rash – a case report

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