1997
DOI: 10.1016/s0006-3223(97)00351-x
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Psychiatric Symptoms in a Patient with Diabetes Mellitus Associated with Point Mutation in Mitochondrial DNA

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Cited by 21 publications
(7 citation statements)
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“…Psychiatric symptoms are associated with mitochondrial encephalomyopathies. Patients affected by MELAS may experience delusions and hallucinations due to delirium or schizophrenic‐like symptoms, sometimes before the clinical diagnosis is established 88, 89, 146. In some cases they can be regarded as directly related to neuronal dysfunction 199…”
Section: Mitochondrial Encephalomyopathiesmentioning
confidence: 99%
“…Psychiatric symptoms are associated with mitochondrial encephalomyopathies. Patients affected by MELAS may experience delusions and hallucinations due to delirium or schizophrenic‐like symptoms, sometimes before the clinical diagnosis is established 88, 89, 146. In some cases they can be regarded as directly related to neuronal dysfunction 199…”
Section: Mitochondrial Encephalomyopathiesmentioning
confidence: 99%
“…47 Comorbidity with mitochondrial disease Patients with MELAS sometimes demonstrate delusions and hallucinations due to delirium [48][49][50][51] or schizophrenialike symptoms. [52][53][54][55][56][57][58][59] Of these, delusions and hallucinations due to delirium [48][49][50][51] can be regarded as directly related to neuronal dysfunction due to MELAS. Two of the 3243 mutation cases without any central nervous system symptoms except for schizophrenia, 58,59 and four patients with MELAS who demonstrated schizophrenia long before onset of MELAS have been reported.…”
Section: Schizophreniamentioning
confidence: 99%
“…[52][53][54][55][56][57][58][59] Of these, delusions and hallucinations due to delirium [48][49][50][51] can be regarded as directly related to neuronal dysfunction due to MELAS. Two of the 3243 mutation cases without any central nervous system symptoms except for schizophrenia, 58,59 and four patients with MELAS who demonstrated schizophrenia long before onset of MELAS have been reported. [52][53][54][55] These six cases, however, may represent occasional comorbidity of MELAS and schizophrenia in view of the high rate of schizophrenia in the general population.…”
Section: Schizophreniamentioning
confidence: 99%
“…However, the deletions, insertions, modifications, and other rearrangements described in these studies represent damage done to mtDNA in the liver, white blood cells, and elsewhere as a consequence of oxidative stress associated with chronic ethanol consumption [1,2]. Only a small number of studies have detected associations between mtDNA polymorphisms and psychiatric disorders and syndromes that overlap those of chronic alcoholism [3,4]. These observations, plus the possibility that heritable mtDNA mutations could influence susceptibility to alcohol-induced oxidative stress damage, motivate our current study in which we analyze data from the Collaborative Study of the Genetics of Alcoholism (COGA) [5] to detect and characterize mitochondrial genetic effects on variation in latent class psychiatric/behavioral variables.…”
Section: Introductionmentioning
confidence: 99%