Psychiatric Symptoms in Frontotemporal Dementia: Epidemiology, Phenotypes, and Differential Diagnosis

Galimberti, Daniela; Dell’Osso, Bernardo; Altamura, A.C.; Scarpini, Elio

doi:10.1016/j.biopsych.2015.03.028

Cited by 110 publications

(106 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies found associations of neurodegenerative and psychiatric disorders with ALS, but were not able to examine the temporal relation with ALS onset [11][12][13][14]19] . The type of analysis performed, that is, survival analysis, which considers the exposure to drugs as time-dependent variables, has allowed to classify correctly exposed and non-exposed periods at the individual level and to compute appropriately exposed and non-exposed person-years.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies showed an increased risk of psychotic manifestations and other neurodegenerative disorders associated in ALS patients and their family aggregates [11][12][13][14] , even if antipsychotic and antidepressant drugs have been hypothesized to be protective toward ALS onset [15] . On the basis of these data, and since no longitudinal studies have been conducted on the association between ALS onset and previous nervous system drugs consumption, the aim of the present study was to assess whether drugs acting on nervous system could have an effect on the development of ALS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

et al. 2016

View full text Add to dashboard Cite

Background: An increased frequency of psychotic disorders in amyotrophic lateral sclerosis (ALS) families compared to controls has been reported. Aim of our study was to assess the relationship between nervous system drugs prescriptions and subsequent onset of ALS in a large Italian population. Methods: The study population consisted of all subjects over 15 years at the 2001 Italian census, resident in Turin since 1996 (n = 687,324), followed up for ALS occurrence from 2002 to 2014. Exposure to nervous system drugs was measured until 2012, or until 1 year before ALS onset. The association was estimated for ever and cumulative exposure, through Cox proportional Hazards models adjusted for sex, age, education, marital status and drug co-exposure. Results: In the analysis for ever exposure, opioids were significantly inversely associated with ALS risk (hazard ratio (HR) 0.59; 95% CI 0.35-0.97), while antiepileptics (HR 1.35; 95% CI 0.92-2.00) showed a marginally significantly positive association. Examining cumulative exposure, the protective role of opioids associated with more than 4 prescriptions and the risk effect of antiepileptics for over 6 prescriptions was confirmed. Conclusions: The present study revealed associations of ALS onset with previous exposure to opioids, maybe through the activation of δ receptor and σ receptors and antiepileptics, which are novel findings to our knowledge.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The relationship of source memory to the pathogenesis of hallucinations is unclear, though hearing voices (the most common hallucinatory experience in schizophrenia) likely involves a disruption in source monitoring of internally generated ideation (or subvocal speech) [49, 50], and accelerated gray matter loss among converters to psychosis has been observed in regions relevant to both source monitoring and auditory verbal processing [20, 22]. A focus on deficits in network interactions supporting source memory may also help to explain the appearance of psychotic symptoms in patients with frontotemporal dementia [51], as well as the observation of relatively greater deficits in episodic memory among cases of mood disorders with psychotic features than among cases without psychotic features [52]. …”

Section: Neurodevelopment Medial Prefrontal Cortex and Errors In Somentioning

confidence: 99%

How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis

Cannon

2015

Trends in Cognitive Sciences

195

145

View full text Add to dashboard Cite

Identifying cognitive and neural mechanisms involved in the development of schizophrenia requires longitudinal observation of individuals prior to onset. Here recent studies of prodromal individuals who progress to full psychosis are briefly reviewed in relation to models of schizophrenia pathophysiology. Together, this body of work suggests that disruption in brain connectivity, driven primarily by a progressive reduction in dendritic spines on cortical pyramidal neurons, may represent a key triggering mechanism. The earliest disruptions appear to be in circuits involved in referencing experiences according to time, place, and agency, which may result in a failure to recognize particular cognitions as self-generated or to constrain interpretations of the meaning of events based on prior experiences, providing the scaffolding for faulty reality testing.

show abstract

“…The difficulty in separating pure psychiatric disease from neurological disease may be particularly true in hereditary neurodegenerative diseases such as Huntington disease and Frontotemporal dementia. (Zanardini et al 2016;Lanata and Miller 2016;Galimberti et al 2015;Wylie et al 2013;Paulsen 2010;Epping et al 2016;Julien et al 2007;Hallam et al 2007;Woolley et al 2011;Ducharme et al 2015) As we learn more about these illnesses, it is apparent that the earliest symptoms of some of them are frequently psychiatric, but often mischaracterized as having a primary psychiatric, rather than neurological, etiology (Duff et al 2010;Paulsen 2010;Paulsen et al 2008;Epping et al 2016;Julien et al 2007;Hallam et al 2007;Woolley et al 2011;Block 2015;Ducharme et al 2015;Reilmann et al 2014;Tabrizi et al 2013;Reedeker).…”

Section: Introductionmentioning

confidence: 99%

The Confluence of Psychiatric Symptoms and Neurodegenerative Disease: Impact on Genetic Counseling

Goldman

Huey

Thorne

2016

Journal of Genetic Counseling

View full text Add to dashboard Cite

Hereditary neurodegenerative diseases can present with a psychiatric prodrome that overlaps with psychiatric symptoms that are not primary to these diseases. When individuals present for predictive testing while experiencing such symptoms, clinicians including genetic counselors, must proceed with caution and evaluate each situation on a case-by-case basis. Legitimate reasons may exist for moving forward with testing. Additionally predicting the consequences of testing is unrealistic so that the clinicians must do their best to prepare patients for both positive and negative results. A multidisciplinary team following the Huntington disease protocol remains the gold standard care for predictive testing for such patients. We discuss 3 case histories that demonstrate the complex nature of genetic counseling and testing in the presence of psychiatric symptoms, whether emanating from the disease itself or the results of living in an affected family.

show abstract

Psychiatric Symptoms in Frontotemporal Dementia: Epidemiology, Phenotypes, and Differential Diagnosis

Cited by 110 publications

References 94 publications

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis

The Confluence of Psychiatric Symptoms and Neurodegenerative Disease: Impact on Genetic Counseling

Contact Info

Product

Resources

About