Psychiatry and the ‘new genetics’: hunting for genes for behaviour and drug response

Aitchison, Katherine J.; Basu, Amlan; McGuffin, Peter; Craig, Ian W.

doi:10.1192/bjp.186.2.91

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…The genetic association studies mentioned above were based on the investigation of single polymorphisms. However, it will probably soon be feasible to analyse 100 000 SNPs simultaneously using microarray technology (Aitchison, Basu, McGuffin, & Craig, 2005). The same technology can also be used to examine gene expression as RNA on a large scale, allowing the investigation of gene function as well as structural variation.…”

Section: Future Prospectsmentioning

confidence: 99%

Genetics and delusional disorder

Cardno

McGuffin²

2006

Behavioral Sci & The Law

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This article gives an overview of genetic research approaches and their application to delusional disorder. Most studies have been based on small samples and have had other methodological limitations, so it is not clear whether there is a genetic contribution to the aetiology of delusional disorder. It is unlikely that delusional disorder is strongly related genetically to affective disorder or schizophrenia, but more subtle relationships cannot be ruled out. The rarity of multiply affected families prohibits linkage studies and, to date, molecular genetic investigations have been mainly limited to small association studies of dopamine receptor polymorphisms. A range of considerably larger, epidemiologically rigorous studies is required, but the uncommonness and other features of the disorder put strong limitations on the prospects for ascertaining adequate samples.

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Section: Future Prospectsmentioning

confidence: 99%

Genetics and delusional disorder

Cardno

McGuffin²

2006

Behavioral Sci & The Law

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“…For instance, it may well be that people in collectivistic cultures are on average more responsive to psychosocial interventions compared with people in more individualistic cultures given their sensitivity to their environment. With increasing insights into gene-environment transactions, the hunt for genes that might predict treatment response is now in progress 14 , but these genes might differ considerably between cultures, again emphasizing the need to consider cross-national data sets in the identification of effective treatments.…”

Section: I a L D I S T R I B U T I O N U N A U T H O R I Z E D U S mentioning

confidence: 99%

Treatment of depression: are we finally on the right track?

Luyten¹

2013

Current Medical Research and Opinion

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“…Saarelainen et al [64] found that trkB.T1-overexpressing transgenic mice, which show reduced trkB (BDNF receptor) activation in the brain, and heterozygous BDNF-null (BDNF+/-) mice were resistant to the effects of antidepressants in the forced swim test, indicating that normal trkB signalling is required for the behavioral effects typically produced by antidepressants. Association studies including BDNF are ongoing (the GENDEP project [65]). …”

Section: Using Hypothesis-driven Candidate Genes For Depression and Nmentioning

confidence: 99%

The genetics of depression and related traits

Huezo-Diaz

Tandon²,

Aitchison³

2005

Curr Psychiatry Rep

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There is considerable evidence that genetic factors play a major role in the etiology of unipolar depression. Investigations into vulnerability genes for unipolar depression are underway and for more broadly defined depression-related traits, such as anxiety, neuroticism, and harm avoidance. This review discusses some of the core issues related to study design and molecular genetic methodology, followed by an overview of recent molecular genetic findings for unipolar depression. The research to date has identified regions within certain chromosomes that may contain risk genes. Improved study design and the use of new molecular techniques hold promise for the identification of more specific vulnerability genes for unipolar depression.

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Psychiatry and the ‘new genetics’: hunting for genes for behaviour and drug response

Cited by 15 publications

References 13 publications

Genetics and delusional disorder

Genetics and delusional disorder

Treatment of depression: are we finally on the right track?

The genetics of depression and related traits

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