Psychiatry is Neurology: White matter pathology permeates psychiatric disorders

Depression and schizophrenia: Many biological and clinical similarities

“…The overlap is also consistent with the emerging transdiagnostic model of psychopathology. [1][2][3][4][5][6][7][8][9] This model proposes that there is a "core" genetic risk for psychopathology with different iterations. The transdiagnostic model is in stark contrast to the prevailing DSM-5, which categorizes psychiatric disorders in "silos," as if they are completely independent from each other despite many shared features.…”

Contemporary psychiatry: A SWOT analysis

“…• The DSM diagnostic system needs a paradigm shift: it is still based on a menu of clinical signs and symptoms and is devoid of objective diagnostic measures such as biomarkers 4 • Neuroscience literacy among busy psychiatric practitioners is insufficient at a time of explosive growth in basic and clinical neuroscience 13 • No effective treatment for alcohol or substance use disorders despite their very high morbidity and mortality…”

“…• Powerful new data management tools, including machine learning, artificial intelligence, super computers, big data, deep learning, nanotechnology, and metabolomics, all of which are expediting neurobiological discoveries 16 • The potential of reclassifying psychiatric disorders as neurological disorders, which will improve reimbursement for patient health care and reduce stigma 17 • Emergence of new mechanisms of action of disease etiology, such as microbiota, mitochondrial dysfunction, permeable blood-brain barrier, and neuroimmune dysregulation 18,19 • The advent and growth of "precision psychiatry" 20 • The tremendous potential of molecular genetics and gene therapy for psychiatric disorders, most of which are genetic in etiology…”